Evidence map›Paper›PMID 32515676›Full record

ArticleRadiology2020

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19.

Eléonore Blondiaux, Pauline Parisot, Alban Redheuil, Lucile Tzaroukian, Yaël Levy, Chiara Sileo, Aurélie Schnuriger, Mathie Lorrot, Romain Guedj, Hubert Ducou le Pointe

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 14 pooled it
44.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 14 syntheses or guidelines pooled it, 226 citations in OpenAlex.

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  13. Kawasaki-like disease in children with COVID-19.Rheumatology international · 2020
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Eléonore BlondiauxFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0002-2594-5428
Pauline ParisotFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).
Alban RedheuilFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).
Lucile TzaroukianFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).
Yaël LevyFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0002-5325-5838
Chiara SileoFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0001-6406-1951
Aurélie SchnurigerFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0003-0931-8720
Mathie LorrotFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).
Romain GuedjFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0002-9497-4396
Hubert Ducou le PointeFrom the Department of Imaging (E.B., C.S., H.D.l.P.), Pediatric Cardiovascular Unit (P.P.), Neonatal and Pediatric Intensive Care Unit (L.T., Y.L.), Virology Laboratory (A.S.), Department of Pediatrics (M.L.), and Pediatric Emergency Department (R.G.), Hôpital Trousseau-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Hôpital Armand-Trousseau, 26 Avenue du Dr Arnold Netter, 75012 Paris, France; Biomedical Imaging Laboratory, Sorbonne Université, INSERM, CNRS, Paris, France (E.B., A.R.); Department of Cardiovascular and Thoracic Imaging and Interventional Radiology, Institute of Cardiology, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux Parisiens (AP-HP), Sorbonne Université, Paris, France (A.R.); and INSERM Laboratory U955-PHYDES-IMRB-Pharmacological and Therapeutic Strategies for Myocardial Ischemia and Heart Failure, Ecole Vétérinaire, Maisons-Alfort, France (Y.L.).ORCID 0000-0002-6667-8629
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case series examines cardiac MRI findings in four children and adolescents admitted to intensive care in April 2020 for multisystem inflammatory syndrome and Kawasaki disease-like features related to coronavirus disease 2019 (COVID-19). Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. Physical examination showed rash and cheilitis or conjunctivitis. All patients recovered after intravenous immunoglobulin therapy. Severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction was negative in nasopharyngeal, stool, and respiratory samples and was positive on serology. Cardiac MRI showed diffuse myocardial edema on T2 short tau inversion-recovery sequences and native T1 mapping, with no evidence of late gadolinium enhancement suggestive of replacement fibrosis or focal necrosis. These findings favor postinfectious myocarditis in children and adolescents with COVID-19.

Indexed as

BetacoronavirusChildCoronavirus InfectionsCOVID-19FemaleHeartHumansImmunoglobulins, IntravenousMagnetic Resonance ImagingMaleMyocarditisPandemicsPneumonia, ViralSARS-CoV-2Systemic Inflammatory Response SyndromeTreatment OutcomeImmunoglobulins, Intravenous

Identifiers

PMID32515676
PMCPMC7294821
OpenAlexW3033853571

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.