ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.
Open access · greenAbstract read
In one paragraph
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Integrated two-photon and photoacoustic microscopy for single-cell neurometabolic imaging.Nature communications · 2026Article
- Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.Nature communications · 2026Article
- Super-resolution functional photoacoustic microscopy via label-free cell tracking.Light, science & applications · 2026Article
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Diurnal differences in cerebral microvascular blood flow and oxygen delivery across brain regions in awake mice.Neurophotonics · 2026Article
- Non-degenerate two-photon imaging of deep rodent cortex using indocyanine green in the water absorption window.Biomedical optics express · 2024Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Quantitative Optical Imaging of Oxygen in Brain Vasculature.The journal of physical chemistry. B · 2024Review
- Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Non-Degenerate Two-Photon Imaging of Deep Rodent Cortex using Indocyanine Green in the water absorption window.bioRxiv : the preprint server for biology · 2024Article
- Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.eLife · 2023Article
- Biocompatible Phosphorescent OBiosensors · 2023Article
- Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury.Neurophotonics · 2023Review
- Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.bioRxiv : the preprint server for biology · 2023Article
- Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases.Nutrients · 2023Review
- Baseline oxygen consumption decreases with cortical depth.PLoS biology · 2022Article
- Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy.STAR protocols · 2022Article
- The oxygen initial dip in the brain of anesthetized and awake mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
İkbal ŞencanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-2903-041X
Tatiana EsipovaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kıvılcım KılıçDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Baoqiang LiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Michèle DesjardinsDepartment of Physics, Engineering Physics and Optics, Université Laval, QC, Canada.
Mohammad A YaseenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Hui WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jason E PorterAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sreekanth KuraDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Buyin FuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Timothy W SecombDepartment of Physiology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-0176-5502
David A BoasDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anna DevorAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sava SakadžićAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Harvard University · USBoston University · USUniversity of Pennsylvania · USUniversité Laval · CAUniversity of Arizona · US
Funding
Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3MMICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6MExpanding the Reach of Evidence-Based Mental Health Treatment: Diffusion and Spillover of Mental Health Benefits Among Peer Networks and Caregivers of Youth Facing Compounded Adversity in Sierra LeoneR01MH117359 · NIMH · BOSTON COLLEGE · PI BETANCOURT, THERESA STICHICK · 2019 to 2023
$3.4MRelating Neuroimmune and Neurovascular Alterations During Alzheimer's Disease ProgressionR01AA027097 · NIAAA · NORTHEASTERN UNIVERSITY · PI YASEEN, MOHAMMAD ABBAS · 2018 to 2022
$2.7MTwo-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4MMultiscale modeling of cerebral blood flow and oxygen transportU01HL133362 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2017 to 2021
$2.0MEffects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9MOxygen imaging by phosphorescence quenchingU24EB028941 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2019 to 2023
$1.6MEnabling widespread use of high resolution imaging of oxygen in the brainR24NS092986 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BOAS, DAVID A, VINOGRADOV, SERGEI · 2015 to 2018
$1.2MIn Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime MicroscopyR00AG042026 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YASEEN, MOHAMMAD ABBAS · 2015 to 2017
$747kVolumetric optical connectome microscopy of human cerebellar circuitryR00EB023993 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, HUI · 2020 to 2022
$747kExploring preclinical amyloid pathology with optical microscopyR56AG058849 · NIA · NORTHEASTERN UNIVERSITY · PI YASEEN, MOHAMMAD ABBAS · 2019 to 2019
$432kNIMH NIH HHS K99 MH120053NIMH NIH HHS R01 MH117359NINDS NIH HHS R24 NS092986
Abstract
The cerebral cortex has a number of conserved morphological and functional characteristics across brain regions and species. Among them, the laminar differences in microvascular density and mitochondrial cytochrome c oxidase staining suggest potential laminar variability in the baseline O
Indexed as
AnimalsCerebral CortexCerebrovascular CirculationFemaleHemodynamicsMiceMice, Inbred C57BLMicroscopyNeurovascular CouplingOptical ImagingOxygenWakefulnessOxygencortical layersIntravascular partial pressure of oxygenneurovascular couplingoxygen extraction fractiontwo-photon microscopy
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.