Evidence map›Paper›PMID 32515560›Full record

ArticleBrain and behavior2020

Left ventricular ejection fraction as an independent predictor of poor outcome in acute intracerebral hemorrhage.

Guang Yang, Lu Wang, Jingxian Sun, Daming Zhang, Ruotian Zhang, Chao Yuan, Meixin Long, Yingqiang Zhong, Chunmei Li, Xiaoxiong Wang and 8 more

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Guang YangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID 0000-0002-7173-1914
Lu WangDepartment of Urology, The Fourth Hospital of Harbin Medical University, Harbin, China.ORCID 0000-0002-8346-194X
Jingxian SunDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Daming ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ruotian ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chao YuanDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Meixin LongDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yingqiang ZhongDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chunmei LiDepartment of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China.
Xiaoxiong WangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin ChenDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Qi ZhouResearch Administration Office, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bo LiuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongquan JiangDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ailing LianOperating Room, The First Hospital of Harbin Medical University, Harbin, China.
Ilgiz GareevBashkir State Medical University, Ufa, Russia.ORCID 0000-0002-4965-0835
Lili LiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shiguang ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CNBashkir State Medical University · RUYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
China Postdoctoral Science Foundation 2016M601451China Postdoctoral Science Foundation 2017M620119China Postdoctoral Science Foundation 2018M631964China Postdoctoral Science Foundation 2019T120284Heilongjiang Postdoctoral Fund LBH-TZ19Heilongjiang Postdoctoral Fund LBH-Z16103Heilongjiang Postdoctoral Fund LBH-Z17108National Natural Science Foundations of China 81572482National Natural Science Foundations of China 81601102National Natural Science Foundations of China 81602225National Natural Science Foundations of China 81971135NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

introductionFew studies of the effect of cardiac abnormalities on acute intracerebral hemorrhage (ICH) outcomes have been published. We sought to determine whether the left ventricular ejection fraction (LVEF) is associated with the functional outcome and mortality of acute ICH patients.

methodsWe conducted a retrospective study on 364 acute ICH patients from January to December 2016. The primary outcome was defined by the modified Rankin Scale and mortality at 3 months. The associations between LVEF and outcome were investigated using univariable and multivariable logistic regression models.

resultsDepressed LVEF was significantly associated with a poor functional outcome with an odds ratio [OR] of 0.966, 95% confidence interval (CI) 0.942-0.991, p = .008, and high mortality (OR 0.968 [95% CI 0.943-0.994], p = .015) at 3 months for acute ICH patients by univariate analysis. Multivariable logistic regression analysis indicated that LVEF was an independent predictor of a poor functional outcome (OR 0.961 [95% CI 0.935-0.988], p = .005) and mortality (OR 0.949 [95% CI 0.918-0.981], p = .002). The percentage of acute ICH patients with poor functional outcome (p = .005) and mortality (p = .002) was obviously higher in the group of patients with a LVEF of <50%.

conclusionsLVEF is an independent predictor of functional outcome and mortality at 3 months for acute ICH patients. These findings could provide the evidence needed for prognosis prediction in acute ICH patients.

Indexed as

Stroke VolumeVentricular Function, LeftCerebral HemorrhageFemaleHumansMaleMiddle AgedOdds RatioPrognosisRetrospective Studiesacute intracerebral hemorrhageleft ventricular ejection fractionoutcomepredictor

Identifiers

PMID32515560
PMCPMC7375101
OpenAlexW3033134913

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.