Evidence map›Paper›PMID 32515358›Full record

ArticleJournal of biosciences2020

Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.

Arindam Maitra, Mamta Chawla Sarkar, Harsha Raheja, Nidhan K Biswas, Sohini Chakraborti, Animesh Kumar Singh, Shekhar Ghosh, Sumanta Sarkar, Subrata Patra, Rajiv Kumar Mondal and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.

  1. The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Article
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  15. Review
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  18. Article
  19. Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Arindam MaitraNational Institute of Biomedical Genomics, PO: NSS, Kalyani 741 251, India.
Mamta Chawla Sarkar
Harsha Raheja
Nidhan K Biswas
Sohini Chakraborti
Animesh Kumar Singh
Shekhar Ghosh
Sumanta Sarkar
Subrata Patra
Rajiv Kumar Mondal
Trinath Ghosh
Ananya Chatterjee
Hasina Banu
Agniva Majumdar
Sreedhar Chinnaswamy
Narayanaswamy Srinivasan
Shanta Dutta
Saumitra DAS
National Institute of Biomedical Genomics · INNational Institute of Cholera and Enteric Diseases · INIndian Institute of Science Bangalore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct massively parallel sequencing of SARS-CoV-2 genome was undertaken from nasopharyngeal and oropharyngeal swab samples of infected individuals in Eastern India. Seven of the isolates belonged to the A2a clade, while one belonged to the B4 clade. Specific mutations, characteristic of the A2a clade, were also detected, which included the P323L in RNA-dependent RNA polymerase and D614G in the Spike glycoprotein. Further, our data revealed emergence of novel subclones harbouring nonsynonymous mutations, viz. G1124V in Spike (S) protein, R203K, and G204R in the nucleocapsid (N) protein. The N protein mutations reside in the SR-rich region involved in viral capsid formation and the S protein mutation is in the S

Indexed as

BetacoronavirusCoronavirus InfectionsDisease OutbreaksHost Microbial InteractionsMutationPandemicsPneumonia, ViralRNA, ViralCOVID-19HumansIndiaSARS-CoV-2RNA, Viral

Identifiers

PMID32515358
PMCPMC7269891
OpenAlexW3033926214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.