ArticleeLife2020
Delineating the early transcriptional specification of the mammalian trachea and esophagus.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Respiratory and other organ manifestations inFrontiers in medicine · 2025Pooled it
- Foxe1 deficiency impairs thyroid fate while supporting lung differentiation.EMBO reports · 2026Article
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- Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting.Nature communications · 2025Article
- An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification.Nature communications · 2025Article
- Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting.bioRxiv : the preprint server for biology · 2025Article
- The molecular and cellular choreography of early mammalian lung development.Medical review (2021) · 2024Review
- Mammalian esophageal stratified tissue homeostasis is maintained distinctively by the epithelial pluripotent p63Cellular and molecular life sciences : CMLS · 2023Article
- NK2 homeobox gene cluster: Functions and roles in human diseases.Genes & diseases · 2023Review
- Article
- iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage.Disease models & mechanisms · 2022Article
- Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types.Development (Cambridge, England) · 2022Article
- Mapping the adult human esophagus in vivo and in vitro.Development (Cambridge, England) · 2022Article
- The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development.Development, growth & differentiation · 2022Article
- Article
- Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.Cell reports · 2022Article
- Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors.iScience · 2022Article
- BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.Nature communications · 2022Article
- Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis.Nature biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combining single-cell RNA-sequencing with bulk RNA-sequencing of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.