Evidence map›Paper›PMID 32515262›Full record

ArticleJournal of neurotrauma2021

B-Cell Lymphoma 2 (Bcl-2) Gene Is Associated with Intracranial Hypertension after Severe Traumatic Brain Injury.

Hansen Deng, Benjamin E Zusman, Enyinna L Nwachuku, John K Yue, Yue-Fang Chang, Yvette P Conley, David O Okonkwo, Ava M Puccio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hansen DengDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Benjamin E ZusmanDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Enyinna L NwachukuDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
John K YueDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.
Yue-Fang ChangDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Yvette P ConleySchool of Nursing and Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Ava M PuccioDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh Medical Center · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

Genomic Variability and Symptomatology After Traumatic Brain InjuryR01NR013342 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2011 to 2013
$1.2M
Mitochrondrial Genetics of Recovery After Brain InjuryR01NR008424 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2005 to 2008
$1.0M
Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and OutcomesR00NR013176 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PUCCIO, AVA M. · 2014 to 2016
$724k
NINR NIH HHS R00 NR013176NINR NIH HHS R01 NR008424NINR NIH HHS R01 NR013342
6 · The paper itself

Abstract

Severe traumatic brain injury (TBI) activates the apoptotic cascade in neurons and glia as part of secondary cellular injury. B-cell lymphoma 2 (

Indexed as

GenotypePolymorphism, Single NucleotideAdolescentAdultAgedAged, 80 and overApoptosisBrain Injuries, TraumaticCerebrovascular CirculationFemaleHumansIntracranial HypertensionIntracranial PressureMaleMiddle AgedProspective StudiesBCL2 protein, humanProto-Oncogene Proteins c-bcl-2apoptosisBcl-2genotypeintracranial hypertensiontraumatic brain injury

Identifiers

PMID32515262
PMCPMC8182479
OpenAlexW3034072924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.