Evidence map›Paper›PMID 32514991›Full record

ArticleJournal of nephrology2020

Plant-based diets, insulin sensitivity and inflammation in elderly men with chronic kidney disease.

Ailema González-Ortiz, Hong Xu, Carla M Avesani, Bengt Lindholm, Tommy Cederholm, Ulf Risérus, Johan Ärnlöv, Angeles Espinosa-Cuevas, Juan Jesús Carrero

Open access · hybridAbstract read
In one paragraph

Article in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Pathophysiology and potential treatment of uremic sarcopenia.Kidney research and clinical practice · 2026
    Article
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  9. Plant-based diets in patients with chronic kidney disease.Asian biomedicine : research, reviews and news · 2024
    Review
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  18. Nutritional status, hyperkalaemia and attainment of energy/protein intake targets in haemodialysis patients following plant-based diets: a longitudinal cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ailema González-OrtizDepartment of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Nobels väg 12A, Box 281, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8891-9892
Hong XuDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7266-3431
Carla M AvesaniRenal Medicine and Baxter Novum, Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4458-8358
Bengt LindholmRenal Medicine and Baxter Novum, Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4269-4293
Tommy CederholmClinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3705-0725
Ulf RisérusClinical Nutrition and Metabolism, Dept. of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-8620-4586
Johan ÄrnlövSchool of Health and Social Studies, Dalarna University, Falun, Sweden.ORCID http://orcid.org/0000-0002-6933-4637
Angeles Espinosa-CuevasNephrology and Mineral Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9153-5155
Juan Jesús CarreroDepartment of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Nobels väg 12A, Box 281, 171 77, Stockholm, Sweden. juan.jesus.carrero@ki.se.ORCID http://orcid.org/0000-0003-4763-2024
Karolinska Institutet · SEUppsala University · SEDalarna University · SEInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn persons with CKD, adherence to plant-based diets is associated with lower risk of CKD progression and death, but underlying mechanisms are poorly characterized. We here explore associations between adherence to plant-based diets and measures of insulin sensitivity and inflammation in men with CKD stages 3-5.

methodsCross-sectional study including 418 men free from diabetes, aged 70-71 years and with cystatin-C estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m

resultsThe majority of men had CKD stage 3a. Hypertension and cardiovascular disease were the most common comorbidities. The median PBDi was 38 (range 14-55). Across higher quintiles of PBDi (i.e. higher adherence), participants were less often smokers, consumed less alcohol, had lower BMI and higher eGFR (P for trend <0.05 for all). Across higher PBDi quintiles, patients exhibited higher insulin sensitivity and lower inflammation (P for trend <0.05). After adjustment for eGFR, lifestyle factors, BMI, comorbidities and energy intake, a higher PBDi score remained associated with higher glucose disposal rate and insulin sensitivity as well as with lower levels of IL-6 and CRP.

conclusionIn elderly men with non-dialysis CKD stages 3-5, adherence to a plant-based diet was associated with higher insulin sensitivity and lower inflammation, supporting a possible role of plant-based diets in the prevention of metabolic complications of CKD.

Indexed as

Insulin ResistanceRenal Insufficiency, ChronicAgedAnimalsCross-Sectional StudiesDiet, VegetarianGlomerular Filtration RateHumansInflammationMaleFruitMalnutritionPotasssiumProtein-energy wastingRestrictionVegetable

Identifiers

PMID32514991
PMCPMC7557485
OpenAlexW3033534433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.