Evidence map›Paper›PMID 32514887›Full record

ArticleMolecular imaging and biology2020

Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study.

Marie-Aline Neveu, Nicolas Beziere, Rolf Daniels, Caroline Bouzin, Arnaud Comment, Johannes Schwenck, Kerstin Fuchs, Manfred Kneilling, Bernd J Pichler, Andreas M Schmid

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  10. HyperpolarizedNMR in biomedicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Marie-Aline NeveuWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Nicolas BeziereWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Rolf DanielsDepartment of Pharmaceutical Technology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Caroline BouzinIREC Imaging Platform, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium.
Arnaud CommentGeneral Electric Healthcare, Pollards Wood, Nightingales Lane, Chalfont St Giles, UK.
Johannes SchwenckWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Kerstin FuchsWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Manfred KneillingWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Bernd J PichlerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany.
Andreas M SchmidWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076, Tuebingen, Germany. a.schmid@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0001-6483-8759
Siemens (Germany) · DEGeneral Electric (United Kingdom) · GBUCLouvain · BEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInflammation is involved in many disease processes. However, accurate imaging tools permitting diagnosis and characterization of inflammation are still missing. As inflamed tissues exhibit a high rate of glycolysis, pyruvate metabolism may offer a unique approach to follow the inflammatory response and disease progression. Therefore, the aim of the study was to follow metabolic changes and recruitment of inflammatory cells after onset of inflammation in arthritic ankles using hyperpolarized 1- PROCEDURE: Experimental rheumatoid arthritis (RA) was induced by intraperitoneal injection of glucose-6-phosphate-isomerase-specific antibodies (GPI) containing serum. To monitor pyruvate metabolism, the transformation of hyperpolarized 1-

resultsHyperpolarized 1-

conclusionsOur study demonstrated the presence of a very early metabolic shift in arthritic joints independent of phagocytic immune cell recruitment. Thus, hyperpolarized 1-

Indexed as

AnimalsAnkleArthritis, RheumatoidCarbon IsotopesFemaleFluorineInflammationJointsLactic AcidLeukocytesMagnetic Resonance SpectroscopyMice, Inbred BALB CMice, Inbred C57BLPyruvic AcidCarbon-13Carbon IsotopesFluorineLactic AcidPyruvic Acid19F-MRIHyperpolarized 13C-MRSImmune imagingLactateRheumatoid arthritis

Identifiers

PMID32514887
PMCPMC7497460
OpenAlexW3033069976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.