Observational studyInternational journal of clinical oncology2020
Association between chronic kidney disease and mortality in stage IV cancer.
Observational study in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Long-term impact of diverting ileostomy after stoma closure on the renal function and risk factors for chronic kidney disease following colorectal tumor surgery.Surgery today · 2026Article
- Renal Involvement in Cancer Patients Undergoing Oncology Therapies: Implications for Personalized Treatment Strategies.Journal of personalized medicine · 2026Article
- Postoperative outcomes of pulmonary resection in patients with non small-cell lung cancer with chronic kidney disease: a retrospective study.Surgery today · 2026Article
- Influence of renal function on the clinical efficacy of carboplatin plus pemetrexed in patients with non-small cell lung cancer.Nagoya journal of medical science · 2025Observational
- Association between total cholesterol levels and all-cause mortality among newly diagnosed patients with cancer.Scientific reports · 2024Article
- Chapter 1: Evaluation of kidney function in patients undergoing anticancer drug therapy, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022.International journal of clinical oncology · 2023Review
- Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients-A Single Center Analysis of 2323 Patients within the Last Decade.Journal of clinical medicine · 2023Article
- The 'other' big complication: how chronic kidney disease impacts on cancer risks and outcomes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Review
- CKD Progression Risk and Subsequent Cause of Death: A Population-Based Cohort Study.Kidney medicine · 2023Article
- Association between lipid variability and the risk of mortality in cancer patients not receiving lipid-lowering agents.Frontiers in oncology · 2023Article
- Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression.Cell death discovery · 2022Article
- Additive interaction of diabetes mellitus and chronic kidney disease in cancer patient mortality risk.Scientific reports · 2022Article
- Risk of malignancy in patients with chronic kidney disease.PloS one · 2022Article
- Association between chronic kidney disease and cancer including the mortality of cancer patients: national health and nutrition examination survey 1999-2014.American journal of translational research · 2022Article
- Exploration of chemotherapy-free regimen after multi-line chemotherapy-induced renal impairment in recurrent ovarian cancer: Case report and literature review.Frontiers in oncology · 2022Article
- Kidney function and cancer risk: An analysis using creatinine and cystatin C in a cohort study.EClinicalMedicine · 2021Article
- Factors Associated with Different Survival Functions in Anticoagulated Patients with Chronic Kidney Disease.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is known to be associated with cancer mortality. However, no study has considered the well-known cancer prognostic factors, ECOG Performance Status (PS) and cancer treatment, as confounding factors. We assessed the independent relationship between CKD and cancer death in stage IV cancer patients.
methodsIn this retrospective observational study, we included stage IV cancer patients diagnosed from 2009 to 2014 in a single center. We collected baseline clinical and laboratory variables, and cancer-specific variables, and assessed the presence of CKD. Our primary outcome was all-cause mortality. The secondary outcome was cancer-specific mortality and site-specific cancer mortality.
resultsAmong 961 eligible stage IV cancer patients (median age 69 years, 51.8% male), 150 patients had CKD. During follow-up (median 9.8 months), 638 patients died, of whom 526 patients died from cancer. After adjusting for prognostic variables, including ECOG PS and cancer treatment, all-cause mortality and cancer-specific mortality were significantly higher in CKD patients than in non-CKD patients (HR 1.41, 95% CI 1.13-1.77 and HR 1.43, 95% CI 1.12-1.83, respectively). In patients with breast and kidney and urinary tract cancers, CKD was associated with a significantly increased risk of death (HR 7.01, 95% CI 1.47-33.4 and HR 3.33, 95% CI 1.42-7.78, respectively).
conclusionsCKD at the time of stage IV cancer diagnosis was associated with all-cause mortality and cancer-specific mortality. Moreover, the association between CKD and cancer-specific death was site specific for breast cancer and kidney and urinary tract cancer.
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