Evidence map›Paper›PMID 32514871›Full record

SynthesisAging clinical and experimental research2021

Guidelines on exercise testing and prescription for patients at different stages of Parkinson's disease.

Camilla Martignon, Anna Pedrinolla, Federico Ruzzante, Gaia Giuriato, Fabio Giuseppe Laginestra, Raquel Bouça-Machado, Joaquim J Ferreira, Michele Tinazzi, Federico Schena, Massimo Venturelli

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Camilla MartignonDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Anna PedrinollaDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Federico RuzzanteDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Gaia GiuriatoDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Fabio Giuseppe LaginestraDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Raquel Bouça-MachadoInstituto de Medicina Molecular, Lisbon, Portugal.
Joaquim J FerreiraInstituto de Medicina Molecular, Lisbon, Portugal.
Michele TinazziDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Federico SchenaDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Massimo VenturelliDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. massimo.venturelli@univr.it.ORCID http://orcid.org/0000-0002-2469-8787
University of Verona · ITNational Legal Medicine Institute · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise is highly recommended in patients with Parkinson's disease (PD). Exercise-induced amelioration of motor, non-motor, and drug-induced symptoms are widely known. However, specific guidelines on exercise testing and prescription in PD are lacking.

objectiveThis study reviews the literature on exercise-based approaches to the management of symptoms at each stage of the disease and evaluate: (1) the most suitable clinical exercise testing; (2) training programs based on testing outcomes and PD stage; (3) the effects of exercise on antiparkinsonian drugs and to suggest the most effective exercise-medication combination.

methodsA systematic search was conducted using the databases MEDLINE, Google Scholar and, Cochrane Library using "Parkinson's Disease AND Physical therapy", "Training AND Parkinson", "Exercise", "Exercise AND Drug" as key words. In addition, references list from the included articles were searched and cross-checked to identify any further potentially eligible studies.

resultsOf a total of 115 records retrieved, 50 (43%) were included. From these, 23 were included under the rubric "exercise testing"; 20 focused on the effectiveness of different types of exercise in PD motor-functional symptoms and neuroprotective effects, throughout disease progression, were included under the rubric "training protocol prescription"; and 7 concern the rubric "interaction between exercise and medication", although none reported consistent results.

conclusionsDespite the lack of standardized parameters for exercise testing and prescription, all studies agree that PD patients should be encouraged to regularly train according to their severity-related limitations and their personalized treatment plan. In this manuscript, specific guidelines for tailored clinical testing and prescription are provided for each stage of PD.

Indexed as

Parkinson DiseaseAntiparkinson AgentsExercise TestExercise TherapyHumansPrescriptionsQuality of LifeAntiparkinson AgentsGuidelinesParkinson’s diseasePhysical activityTrainingTreatment

Identifiers

PMID32514871
OpenAlexW3033175024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.