Evidence map›Paper›PMID 32514762›Full record

ArticleJournal of molecular modeling2020

Studies on the interfacial behavior of DPPC/DPPG mixed monolayers in the presence of fluoxetine.

Bin Xie, Changchun Hao, Ziyi Zhang, Runguang Sun

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bin XieSchool of Physics and Information Technology, Shaanxi Normal University, Xi'an, 710062, People's Republic of China. xiebin@snnu.edu.cn.ORCID https://orcid.org/0000-0001-9826-4589
Changchun HaoSchool of Physics and Information Technology, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.ORCID https://orcid.org/0000-0002-8900-4694
Ziyi ZhangSchool of Physics and Information Technology, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
Runguang SunSchool of Physics and Information Technology, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
Shaanxi Normal University · CN

Funding

Fundamental Research Funds for the Central Universities 2017TS014, GK201803021, GK201806004National Natural Science Foundation of China No. 11874039
6 · The paper itself

Abstract

In this study, the interfacial behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPC/DPPG) mixed monolayers with fluoxetine (FLX) in the subphase was investigated by a combination of the Langmuir-Blodgett technique and atomic force microscopy (AFM). It was found that DPPC/DPPG mixed monolayers showed different interfacial behaviors before and after addition of FLX in the subphase. The electrostatic interaction between FLX and lipids molecules destroys the homogeneity of the mixed monolayers and changes the arrangement of lipids molecules at the interface after addition of FLX in the subphase, thereby leading to an increase of compressibility and miscibility and a decrease in the stability of the mixed monolayers. The surface morphology of the mixed monolayers observed by AFM was different between without and with FLX in the subphase, indicating the penetration of FLX into the mixed monolayers. The present study has provided detailed information for further understanding the interactions of drugs with membrane lipids in other lipid monolayers.

Indexed as

Membranes, Artificial1,2-DipalmitoylphosphatidylcholineFluoxetineMicroscopy, Atomic ForceModels, MolecularPhosphatidylglycerolsPressureSelective Serotonin Reuptake InhibitorsStatic ElectricitySurface Properties1,2-Dipalmitoylphosphatidylcholine1,2-dipalmitoylphosphatidylglycerolFluoxetineMembranes, ArtificialPhosphatidylglycerolsSelective Serotonin Reuptake InhibitorsAtomic force microscopeElectrostatic interactionFluoxetineInterfacial behaviorMixed monolayers

Identifiers

PMID32514762
OpenAlexW3032900971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.