ArticleInternational journal of colorectal disease2020
The role of apical lymph node metastasis in right colon cancer.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Prognosis of Patients With Colorectal Cancer and Apical Lymph Node Metastasis at the Inferior Mesenteric Artery: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Poor prognosis in stage III colorectal cancer with apical lymph node metastasis: a single-center retrospective study.Updates in surgery · 2025Article
- The significance of lymph node metastasis in pT1-2 colorectal cancer.Journal of gastrointestinal oncology · 2025Article
- D3 lymph node dissection improves perioperative outcomes and overall survival in patients with cT2N0 colorectal cancer.Journal of gastrointestinal oncology · 2025Article
- Development and validation of nomograms for predicting the prognosis of colorectal cancer patients.Translational cancer research · 2025Article
- Evaluation of colon cancer prognostic factors by CT and MRI: an up-to-date review.Abdominal radiology (New York) · 2024Review
- Construction of a nomogram based on clinicopathologic features to predict the likelihood of No. 253 lymph node metastasis in rectal cancer patients.Langenbeck's archives of surgery · 2024Article
- The Clinical Impact of Apical Lymph Node Metastasis of Colorectal Cancer After Curative Resection.Journal of gastrointestinal cancer · 2023Article
- Preoperative computed tomography assessment of circumferential resection margin in retroperitonealized colon cancer predicts disease-free survival.European radiology · 2023Article
- D3 lymph node dissection improves the survival outcome in patients with pT2 colorectal cancer.International journal of colorectal disease · 2023Article
- Current Perspectives on the Importance of Pathological Features in Prognostication and Guidance of Adjuvant Chemotherapy in Colon Cancer.Current oncology (Toronto, Ont.) · 2022Article
- The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer.Scientific reports · 2022Article
- Pathological Features and Prognostication in Colorectal Cancer.Current oncology (Toronto, Ont.) · 2021Review
- The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients' Survival Time.Frontiers in cell and developmental biology · 2021Article
- D3 Lymph Node Dissection Improves Survival Outcomes in Patients With cT2 Colorectal Non-well-differentiated Adenocarcinoma.In vivo (Athens, Greece)Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of apical lymph node (APN) metastasis in colorectal cancer remains controversial. The main purpose of this study is to explore the prognostic value of APN metastasis in patients with right colon cancer.
methodsThis is a retrospective study of patients with stage III right colon cancer between April 2007 and December 2016. Patients who underwent resection of right colon cancers with D3 lymph node dissection were divided into APN-positive (APN+) and APN-negative (APN-) groups according to the postoperative pathological presence or absence of APN metastasis. Relapse-free survival (RFS) and overall survival (OS) between groups were compared after Cox regression analysis and 1:1 propensity score matching (PSM).
resultsA total of 254 patients were included in this study: 28 (11.0%) were APN+ and 226 (89.0%) were APN-. Before matching, the rates of elevated carcinoembryonic antigen (CEA), T3-4 tumor invasion, and N2 lymph node metastasis were significantly higher in the APN+ group (CEA ≥ 5 ng/mL, 53.6% vs. 37.6%, p < 0.001; T3-4, 92.9% vs. 85.4%, p < 0.001; N2 metastasis, 57.1% vs. 20.4%, p < 0.001), and APN+ tumors were associated with significantly higher postoperative relapse rates (39.3% vs. 21.2%; p = 0.03), especially with lung metastases (14.3% vs. 4.0%; p = 0.019), which conferred worse RFS (p = 0.013), although OS was similar (p = 0.078). However, after PSM, there were no apparent between-group differences in RFS (p = 0.29) or overall survival rate (p = 0.637). The Cox regression analysis indicated that lymphatic vessel infiltration and depth of invasion were independent risk factors for OS, while APN+ status was not a significant predictor for RFS or OS.
conclusionsAPN metastasis was not a prognostic indicator for RFS or OS in right colon cancer. However, APN+ patients with elevated CEA levels and deeper tumor invasion should be closely monitored for lung metastasis during postoperative follow-up.
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