ArticleClinical rheumatology2020
The systemic sclerosis patient in the COVID-19 era: the challenging crossroad between immunosuppression, differential diagnosis and long-term psychological distress.
Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Wound Image Quality From a Mobile Health Tool for Home-Based Chronic Wound Management With Real-Time Quality Feedback: Randomized Feasibility Study.JMIR mHealth and uHealth · 2021Trial
- Traditional KoreanInternational journal of molecular sciences · 2026Article
- Autoimmune Skin Diseases in the Era of COVID-19: Pathophysiological Insights and Clinical Implications.Microorganisms · 2025Review
- Management of adrenocortical adenoma in systemic sclerosis: A case report.The Journal of international medical research · 2025Article
- Delayed adverse events following COVID-19 vaccination in patients with systemic sclerosis and other autoimmune diseases: a substudy of the COVAD-2 cohort.Rheumatology international · 2023Article
- Systemic sclerosis.Lancet (London, England) · 2023Review
- Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic.Frontiers in integrative neuroscience · 2023Article
- Spontaneous Pneumo-Mediastinum in a Post-COVID-19 Patient with Systemic Sclerosis.Healthcare (Basel, Switzerland) · 2022Article
- The report and analysis concerning the usefulness of basic telemedicine tools in the skin cancer diagnostic screening process during COVID-19 pandemics.Postepy dermatologii i alergologii · 2022Article
- Psychological Fragility in an Italian Cohort of Systemic Sclerosis Patients During COVID-19 Pandemic Category: Short Communication.Open access rheumatology : research and reviews · 2022Article
- Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil.Advances in rheumatology (London, England) · 2021Observational
- Differential diagnosis of COVID-19 at the chest computed tomography scan: A review with special focus on cancer patients.World journal of radiology · 2021Article
- Impact of Covid-19 on clinical care and lived experience of systemic sclerosis: An international survey from EURORDIS-Rare Diseases Europe.Journal of scleroderma and related disorders · 2021Article
- COVID-19 and systemic sclerosis: analysis of lifestyle changes during the SARS-CoV-2 pandemic in an Italian single-center cohort.Clinical rheumatology · 2021Article
- Impact of COVID-19 on outpatient therapy with iloprost for systemic sclerosis digital ulcers.Journal of scleroderma and related disorders · 2021Article
- Imaging conundrum - COVID-related lung changes or connective tissue disease-related interstitial lung disease.Polish journal of radiology · 2021Article
- Management of Systemic Sclerosis Patients in the COVID-19 Era: The Experience of an Expert Specialist Reference Center.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2021Article
- Late Complications of COVID-19; a Systematic Review of Current Evidence.Archives of academic emergency medicine · 2021Review
- Autoimmune connective tissue diseases in the COVID-19 pandemic.Clinics in dermatologyReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 is a world health emergency which may inevitably affect the management of a complex autoimmune disease such as systemic sclerosis (SSc). Several SSc patients are frail and, in this pandemic, need a careful protection. The COVID-19 infection might complicate the clinical scenario of interstitial lung disease (ILD) in SSc because it determines a severe pneumonia characterized by radiological features similar to SSc-ILD. The striking CT similarities between the 2 diseases make it difficult to distinguish a worsening of SSc-ILD from COVID-19-ILD superinfection. Moreover, other aspects, like isolation during lock down, may cause a significant psychological stress which will pile up on the already difficult contact with the patients for a routine check-up. Moreover, the drug shortage is a real problem in these times. For these reasons, the rheumatologist in daily clinical practice should carefully differentiate the possible COVID-19 infection in order to optimize the patient management. Therefore, the challenge in everyday life will be to achieve in due time the differential diagnosis as well as the long-term psychological impact.Key Points• SSc patients should be encouraged to continue their chronic therapy; in case of immunosuppressive therapy it must be discontinued for safety in case of COVID-19 infection.• Psychological support must be guaranteed to every SSc patients.• COVID-19 pneuminia is hard to distinguish from an interstitial lung disease due to SSc lung involvment.• Data sharing is fundamental for an optimal managment of SSc patients during COVID-19 pandemia.
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