Evidence map›Paper›PMID 32514634›Full record

ArticleBrain structure & function2020

Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems.

Sven Nullmeier, Christoph Elmers, Wolfgang D'Hanis, Kiran Veer Kaur Sandhu, Oliver Stork, Yuchio Yanagawa, Patricia Panther, Herbert Schwegler

Open access · hybridAbstract read
In one paragraph

Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Beyond the γ-aminobutyric acid hypothesis of schizophrenia.Frontiers in cellular neuroscience · 2023
    Review
  4. Review
  5. Article
  6. Article
  7. Behavioral Consequences of a Combination ofFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sven NullmeierInstitute of Molecular and Cellular Anatomy, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany. sven.nullmeier@uni.ulm.de.ORCID http://orcid.org/0000-0002-2162-116X
Christoph ElmersInstitute of Anatomy, Otto-Von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Wolfgang D'HanisInstitute of Anatomy, Otto-Von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Kiran Veer Kaur SandhuDepartment of Genetics and Molecular Neurobiology, Institute of Biology, Otto-Von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Oliver StorkDepartment of Genetics and Molecular Neurobiology, Institute of Biology, Otto-Von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Yuchio YanagawaDepartment of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Patricia PantherDepartment of Neurosurgery, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Herbert SchweglerInstitute of Anatomy, Otto-Von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Otto-von-Guericke-Universität Magdeburg · DEUniversität Ulm · DECenter for Behavioral Brain Sciences · DEGunma University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reductions of glutamate acid decarboxylase (GAD67) and subsequent GABA levels have been consistently observed in neuropsychiatric disorders like schizophrenia and depression, but it has remained unclear how GABAergic dysfunction contributes to different symptoms of the diseases. To address this issue, we investigated male mice haplodeficient for GAD67 (GAD67

Indexed as

Social BehaviorSocial IsolationAnimalsBehavior, AnimalBiogenic AminesBrainCholine O-AcetyltransferaseDisease Models, AnimalGlutamate DecarboxylaseMaleMice, Inbred C57BLMice, TransgenicNeuronsReflex, StartleRotarod Performance TestSerotoninBiogenic AminesCholine O-AcetyltransferaseGlutamate Decarboxylaseglutamate decarboxylase 1SerotoninTyrosine 3-MonooxygenaseDopamineGAD67HippocampusSchizophreniaSocial interactionSocial isolation

Identifiers

PMID32514634
PMCPMC7321906
OpenAlexW3033423271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.