Evidence map›Paper›PMID 32514497›Full record

ReviewJHEP reports : innovation in hepatology2020

Combined alcoholic and non-alcoholic steatohepatitis.

Line Carolle Ntandja Wandji, Viviane Gnemmi, Philippe Mathurin, Alexandre Louvet

Open access · goldAbstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Review
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  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Epigenetics of alcohol-related liver diseases.JHEP reports : innovation in hepatology · 2022
    Review
  20. Frontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Line Carolle Ntandja WandjiService des maladies de l'appareil digestif, Hôpital Huriez, Rue Polonowski, 59037 Lille Cedex, France.
Viviane GnemmiCentre de Biologie-Pathologie, Lille, France.
Philippe MathurinService des maladies de l'appareil digestif, Hôpital Huriez, Rue Polonowski, 59037 Lille Cedex, France.
Alexandre LouvetService des maladies de l'appareil digestif, Hôpital Huriez, Rue Polonowski, 59037 Lille Cedex, France.
Inserm · FRInstitut de Biologie de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.

Indexed as

ACC, acetyl-CoA carboxylaseAlcoholALDALD, alcohol-related liver diseaseASHASH, alcohol-related steatohepatitisASK-1, apoptosis signal-regulating kinase 1BMI, body mass indexCLD, chronic liver diseaseCPT, carnitine palmitoyltransferasediabetesDNL, de novo lipogenesisEASL, European Association for the Study of the LiverER, endoplasmic reticulumFXR, farnesoid X receptorHCC, hepatocellular carcinomaHSD17B13, hydroxysteroid 17-beta dehydrogenase 13IL, interleukinLPS, lipopolysaccharideMBOAT7, membrane bound O-acyl transferase 7MELD, model for end-stage liver diseasemetabolic syndromeNAFLDNAFLD, non-alcoholic fatty liver diseaseNASHNASH, non-alcoholic steatohepatitisobesityOR, odds ratioPAMP, pathogen-associated molecular patternPI3K, phosphatidylinositol-3-kinasePIP3, phosphatidylinositol 3,4,5-triphosphatePNPLA3, palatin-like phospholipase domain-containing 3PRKCE, protein kinase C EpsilonROS, reactive oxygen speciesSREBP-1c, sterol regulatory element binding protein-1cTLR, Toll-like receptorTM6SF2, transmembrane 6 superfamily member 2TNF-α, tumour necrosis factor-αWHO, World Health Organization

Identifiers

PMID32514497
PMCPMC7267467
OpenAlexW3028439600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.