ArticleJGH open : an open access journal of gastroenterology and hepatology2020
Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- The Elucidating Pathways of Steatohepatitis (EPoS) staging system: A reproducible 7-tiered fibrosis scoring system in MASLD.JHEP reports : innovation in hepatology · 2026Article
- Emerging therapies and real-world application of metabolic dysfunction-associated steatotic liver disease treatment.Clinical and molecular hepatology · 2025Review
- Survey on Awareness and Implementation Rate of Ultrasound Elastography and Attenuation Imaging.Internal medicine (Tokyo, Japan) · 2025Article
- Therapeutic Strategies for MASH: An Update on Drug Candidates Under Investigation in Late-Phase Clinical Trials.International journal of translational medicine (Basel, Switzerland) · 2025Article
- Evaluation of Minimum-to-Severe Global and Macrovesicular Steatosis in Human Liver Specimens: A Portable Ambient Light-Compatible Spectroscopic Probe.Journal of biophotonics · 2024Article
- Liver fat volume fraction measurements based on multi-material decomposition algorithm in patients with nonalcoholic fatty liver disease: the influences of blood vessel, location, and iodine contrast.BMC medical imaging · 2024Article
- Protocol for a Longitudinal Cohort Study to Understand Characteristics and Risk Factors Underlying Vibration-Controlled Transient Elastography-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Metabolic Dysfunction-Associated Steatohepatitis Detected by Neutrophilic Crown-Like Structures in Morbidly Obese Patients: A Multicenter and Clinicopathological Study.Research (Washington, D.C.) · 2024Article
- Change in Liver Fibrosis Associates with Progress of Diabetic Nephropathy in Patients with Nonalcoholic Fatty Liver Disease.Nutrients · 2023Article
- Vibration-controlled Transient Elastography in NAFLD: Review Study.Euroasian journal of hepato-gastroenterology · 2022Review
- Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease.Hepatology (Baltimore, Md.) · 2022Article
- Article
- Magnetic resonance elastography plus Fibrosis-4 versus FibroScan-aspartate aminotransferase in detection of candidates for pharmacological treatment of NASH-related fibrosis.Hepatology (Baltimore, Md.) · 2022Article
- Artificial neural network in the discrimination of lung cancer based on infrared spectroscopy.PloS one · 2022Article
- Effect of skin-capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease.Scientific reports · 2021Article
- Diagnostic Accuracy of Non-Imaging and Ultrasound-Based Assessment of Hepatic Steatosis Using Controlled Attenuation Parameter (CAP) as Reference.Journal of clinical medicine · 2021Article
- Human Genetics to Identify Therapeutic Targets for NAFLD: Challenges and Opportunities.Frontiers in endocrinology · 2021Review
- Article
- Diagnostic Accuracy of FibroScan and Factors Affecting Measurements.Diagnostics (Basel, Switzerland) · 2020Review
- Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.Journal of medical ultrasonics (2001) · 2020Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver biopsy has been the standard procedure for diagnosing and evaluating the severity of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); however, interobserver discordance remains a critical issue in its pathological diagnosis. METHODS AND
resultsWe examined the concordance rates of pathological scoring and diagnosis between pathologists at individual institutions (local diagnosis) and two central pathologists specialized in liver pathology (central diagnosis). A total of 150 patients with NAFLD underwent prospective liver biopsies. NAFLD activity score (NAS) and fibrosis stage were evaluated, and NASH was determined according to Matteoni's classification. NAS, scores for all NAS components, and fibrosis stage were diagnosed at a lower degree by central compared with local diagnosis. NASH was diagnosed in 34% of the patients according to central pathologists compared with 54% according to local pathologists (
conclusionConcordance rates among pathologists for the evaluation of NAFLD are currently poor, and simple and reliable diagnostic and evaluation criteria are urgently needed to improve the clinical management of NAFLD patients.
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