ArticleRespirology case reports2020
High-dose, short-term corticosteroids for ARDS caused by COVID-19: a case series.
Article in Respirology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Longer Prehospitalization and Preintubation Periods in Intubated Non-survivors and ECMO Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis.Expert review of respiratory medicine · 2020Pooled it
- Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis.Indian journal of pharmacologyPooled it
- A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A High-Dose Corticosteroid Treatment Increases Coronavirus Disease of 2019 Mortality in Intensive Care Units.Turkish journal of pharmaceutical sciences · 2024Article
- Effect of 2 Different High-Dose Methylprednisolone Treatments on Clinical Outcomes in Severe COVID-19 Patients.Thoracic research and practice · 2023Article
- Article
- Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study.Critical care (London, England) · 2023Article
- Early Stage Combination Treatment with Methylprednisolone Pulse and Remdesivir for Severe COVID-19 Pneumonia.International journal of environmental research and public health · 2023Article
- COVID-19 and corticosteroids: a narrative review.Inflammopharmacology · 2022Review
- Lessons from SARS‑CoV‑2 and its variants (Review).Molecular medicine reports · 2022Review
- Double Trouble-COVID-19 and the Widespread Use of Corticosteroids: Are We Staring at an Osteonecrosis Epidemic?Indian journal of orthopaedics · 2022Review
- The impact of calcitriol and estradiol on the SARS-CoV-2 biological activity: a molecular modeling approach.Scientific reports · 2022Article
- Does the intubation timeline affect the in-hospital mortality of COVID-19 patients? A retrospective cohort study.Frontiers in medicine · 2022Article
- Comparison of pulse-dose and high-dose corticosteroids with no corticosteroid treatment for COVID-19 pneumonia in the intensive care unit.Journal of medical virology · 2022Article
- Outcome of Critically Ill COVID-19 Patients According to the Setting of Corticosteroid Initiation-A Retrospective Observational Cohort Study.Journal of personalized medicine · 2021Article
- Acute respiratory distress syndrome in COVID-19: possible mechanisms and therapeutic management.Pneumonia (Nathan Qld.) · 2021Review
- Dismal Survival in COVID-19 Patients Requiring ECMO as Rescue Therapy after Corticosteroid Failure.Journal of personalized medicine · 2021Article
- Comparison of standard dose with high dose of methylprednisolone in the management of COVID-19 patients admitted in ICU.Journal of family medicine and primary care · 2021Article
- Effect of Different Corticosteroid Regimens on the Outcome of Severe COVID-19-Related Acute Respiratory Failure. A Retrospective Analysis.Journal of clinical medicine · 2021Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We report a case series of seven mechanically ventilated patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease (COVID-19) who received early treatment with high-dose, short-term systemic corticosteroids to prevent cytokine overproduction. Of the seven patients, four were male and median age was 69 years. They were intubated within seven days after admission when their respiratory status rapidly worsened. At that time, we administered 1000 or 500 mg/day for three days of methylprednisolone intravenously, followed by 1 mg/kg and tapered off. The median duration for the total administration of corticosteroids was 13 days. This high-dose, short-term corticosteroid therapy enabled extubation of the patients within seven days. Many questions on the clinical management of COVID-19 remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. We present the clinical course of our cases, review the previous evidence, and discuss management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.