ArticleBulletin of the World Health Organization2020
A comparison of five paediatric dosing guidelines for antibiotics.
Article in Bulletin of the World Health Organization, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- A simplified amoxicillin regimen with dose frequency based on post-natal age in neonates with confirmed or suspected infection.Antimicrobial agents and chemotherapy · 2025Observational
- Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections.Antibiotics (Basel, Switzerland) · 2023Article
- Quality indicators for appropriate antibiotic prescribing in urinary tract infections in children.BMC infectious diseases · 2023Review
- Antibiotics needed to treat multidrug-resistant infections in neonates.Bulletin of the World Health Organization · 2022Review
- Environmental impacts of mass drug administration programs: exposures, risks, and mitigation of antimicrobial resistance.Infectious diseases of poverty · 2022Review
- Variation in UK guidelines for the first-line antimicrobial management of paediatric orbital cellulitis-time for national recommendations.Eye (London, England) · 2021Article
- Variation in Target Attainment of Beta-Lactam Antibiotic Dosing Between International Pediatric Formularies.Clinical pharmacology and therapeutics · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare dosing guidance in the paediatric formularies of high- and middle-income countries for 32 commonly prescribed antibiotics on the World Health Organization's (WHO's) 2017
methodsWe identified paediatric antibiotic guidelines that were either widely used internationally or originated from countries in which antibiotic use has increased markedly in recent years (i.e. Brazil, China, India, the Russian Federation and South Africa).
findingsThe study analysis considered five leading antibiotic guidelines: (i) the
conclusionThe pharmacokinetic, pharmacodynamic and clinical evidence supporting paediatric antibiotic dosing, particularly on total doses and on age or weight dosing bands, needs to be improved. Future research should consider whether the variations in guidance identified stem from different clinical disease patterns, varying levels of antibiotic resistance or drug availability rather than historical preferences. Interested global parties could collaborate with WHO's
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.