Evidence map›Paper›PMID 32514197›Full record

SynthesisBulletin of the World Health Organization2020

Herpes simplex virus: global infection prevalence and incidence estimates, 2016.

Charlotte James, Manale Harfouche, Nicky J Welton, Katherine Me Turner, Laith J Abu-Raddad, Sami L Gottlieb, Katharine J Looker

Open access · diamondAbstract readComparative StudySystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Bulletin of the World Health Organization, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 435 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
435citing papers in PubMed, 10 pooled it
51.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

435 citing papers in PubMed, 10 syntheses or guidelines pooled it, 759 citations in OpenAlex.

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375 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Charlotte JamesPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, England.
Manale HarfoucheWeill Cornell Medical College, Doha, Qatar.
Nicky J WeltonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, England.
Katherine Me TurnerBristol Veterinary School, University of Bristol, Bristol, England.
Laith J Abu-RaddadWeill Cornell Medical College, Doha, Qatar.
Sami L GottliebDepartment of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Katharine J LookerPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, England.
Weill Cornell Medical College in Qatar · QAWorld Health Organization · CH

Funding

Enhanced collaboration between US NIH and WHO on biomedical researchU01AI108543 · NIAID · WORLD HEALTH ORGANIZATION · PI TROEDSSON, HANS · 2013 to 2018
$3.7M
NIAID NIH HHS U01 AI108543
6 · The paper itself

Abstract

objectiveTo generate global and regional estimates for the prevalence and incidence of herpes simplex virus (HSV) type 1 and type 2 infection for 2016.

methodsTo obtain data, we undertook a systematic review to identify studies up to August 2018. Adjustments were made to account for HSV test sensitivity and specificity. For each World Health Organization (WHO) region, we applied a constant incidence model to pooled prevalence by age and sex to estimate the prevalence and incidence of HSV types 1 and 2 infections. For HSV type 1, we apportioned infection by anatomical site using pooled estimates of the proportions that were oral and genital.

findingsIn 2016, an estimated 491.5 million people (95% uncertainty interval, UI: 430.4 million-610.6 million) were living with HSV type 2 infection, equivalent to 13.2% of the world's population aged 15-49 years. An estimated 3752.0 million people (95% UI: 3555.5 million-3854.6 million) had HSV type 1 infection at any site, equivalent to a global prevalence of 66.6% in 0-49-year-olds. Differing patterns were observed by age, sex and geographical region, with HSV type 2 prevalence being highest among women and in the WHO African Region.

conclusionAn estimated half a billion people had genital infection with HSV type 2 or type 1, and several billion had oral HSV type 1 infection. Millions of people may also be at higher risk of acquiring human immunodeficiency virus (HIV), particularly women in the WHO African Region who have the highest HSV type 2 prevalence and exposure to HIV.

Indexed as

AdolescentAdultAge DistributionChildChild, PreschoolFemaleGlobal HealthHerpes GenitalisHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanHumansIncidenceInfantMaleMiddle Aged

Identifiers

PMID32514197
PMCPMC7265941
OpenAlexW3022275668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.