ArticleNature genetics2020
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
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In one paragraph
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 339 papers, 21 of them syntheses that pooled it.
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0cells of the map it votes in
339citing papers in PubMed, 21 pooled it
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
339 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.Nature communications · 2026Pooled it
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- Genetic study identifies novel genes in developmental dysplasia of the hip.Bone research · 2026Pooled it
- Early diagnostic value of novel biomarkers for breast cancer therapy-related cardiac dysfunction.ESC heart failure · 2025Pooled it
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations.PLoS genetics · 2025Pooled it
- Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.Nature communications · 2025Pooled it
- The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis.Lipids in health and disease · 2025Pooled it
- Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.Cell genomics · 2025Pooled it
- Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.Nature communications · 2025Pooled it
- Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population.Leukemia · 2025Pooled it
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Coffee and Risk of Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization Analyses.Nutrients · 2024Pooled it
- Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project.Cancer causes & control : CCC · 2024Pooled it
- Pooled it
- Proteome-wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8-year prospective study.Aging cell · 2024Pooled it
- Genetically mimicked effects of thyroid dysfunction on diabetic retinopathy risk: a 2-sample univariable and multivariable Mendelian randomization study.Frontiers in endocrinology · 2024Pooled it
- East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease.Nature genetics · 2023Pooled it
- Identification of 13 Novel Loci in a Genome-Wide Association Study on Taiwanese with Hepatocellular Carcinoma.International journal of molecular sciences · 2023Pooled it
- GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture.Nature genetics · 2023Pooled it
279 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
89 authors.
Kazuyoshi IshigakiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-2881-0657
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Masahiro KanaiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-5165-4408
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7099-8767
Eiryo KawakamiMedical Sciences Innovation Hub Program (MIH), RIKEN, Yokohama, Japan.
Hiroki SugishitaLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6561-8261
Saori SakaueLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-3618-9717
Nana MatobaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-5329-0134
Siew-Kee LowLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6452-4095
Tiffany AmariutaCenter for Data Sciences, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0121-1726
Steven GazalProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4510-5730
Yuta KochiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Momoko HorikoshiLaboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ken SuzukiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-1065-3593
Kaoru ItoLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Satoshi KoyamaLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kouichi OzakiMedical Genome Center, National Center for Geriatrics and Gerontology, Obu, Japan.
Shumpei NiidaMedical Genome Center, National Center for Geriatrics and Gerontology, Obu, Japan.
Yasushi SakataDepartment of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Yasuhiko SakataDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Tohoku, Japan.
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Makoto HirataInstitute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9994-9958
Koichi MatsudaGraduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Masashi IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan.ORCID http://orcid.org/0000-0001-6237-2449
Nakao IwataDepartment of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan.ORCID http://orcid.org/0000-0003-3189-6076
Shiro IkegawaLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0316-2147
Ikuyo KouLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Toshihiro TanakaLaboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hidewaki NakagawaLaboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Akari SuzukiLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Tomomitsu HirotaLaboratory for Respiratory and Allergic Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Mayumi TamariLaboratory for Respiratory and Allergic Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-5755-9177
Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Daiki MikiDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Masaki MoriDepartment of Surgery and Sciences, Graduate School of Medicine, Kyushu University, Fukuoka, Japan.
Satoshi NagayamaDepartment of Gastroenterological Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9632-914X
Yataro DaigoDepartment of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Shiga, Japan.
Yoshio MikiDepartment of Genetic Diagnosis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Toyomasa KatagiriDivision of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan.
Osamu OgawaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Wataru ObaraDepartment of Urology, Iwate Medical University School of Medicine, Iwate, Japan.
Hidemi ItoDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID http://orcid.org/0000-0002-8023-4581
Teruhiko YoshidaDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Issei ImotoDivision of Molecular Genetics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Takashi TakahashiAichi Cancer Center, Nagoya, Japan.
Chizu TanikawaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takao SuzukiTokushukai Group, Tokyo, Japan.
Nobuaki SinozakiTokushukai Group, Tokyo, Japan.
Shiro MinamiDepartment of Bioregulation, Nippon Medical School, Kawasaki, Japan.
Hiroki YamaguchiDepartment of Hematology, Nippon Medical School, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0571-7495
Satoshi AsaiDivision of Pharmacology, Department of Biomedical Science, Nihon University School of Medicine, Tokyo, Japan.
Yasuo TakahashiDivision of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Ken YamajiDepartment of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Kazuhisa TakahashiDepartment of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Tomoaki FujiokaDepartment of Urology, Iwate Medical University School of Medicine, Iwate, Japan.
Ryo TakataDepartment of Urology, Iwate Medical University School of Medicine, Iwate, Japan.ORCID http://orcid.org/0000-0002-4860-8942
Hideki YanaiFukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Akihide MasumotoAso Iizuka Hospital, Fukuoka, Japan.
Yukihiro KoretsuneNational Hospital Organization Osaka National Hospital, Osaka, Japan.
Hiromu KutsumiCenter for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Shiga, Japan.
Masahiko HigashiyamaDepartment of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Shigeo MurayamaDepartment of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Naoko MinegishiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kichiya SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kozo TannoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0001-8307-2461
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Norie SawadaDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9936-1476
Hirokazu UemuraDepartment of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Keitaro TanakaDepartment of Preventive Medicine, Saga University Faculty of Medicine, Saga, Japan.ORCID http://orcid.org/0000-0002-5725-4736
Mariko NaitoDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Makoto SasakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.ORCID http://orcid.org/0000-0002-3108-4361
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4105-2774
Masayuki YamamotoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kazuhiko YamamotoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoshinori MurakamiDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2826-4396
Yusuke NakamuraHuman Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Soumya Raychaudhuri *Center for Data Sciences, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID http://orcid.org/0000-0002-1901-8265
Johji Inazawa *Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. johinaz.cgen@mri.tmd.ac.jp.ORCID http://orcid.org/0000-0002-3945-2800
Toshimasa Yamauchi *Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tyamau-tky@umin.net.ORCID http://orcid.org/0000-0003-4827-6404
Takashi Kadowaki *Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kadowaki-3im@h.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-5428-3582
Michiaki Kubo *RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. michiaki.kubo@riken.jp.ORCID http://orcid.org/0000-0002-0095-2322
Yoichiro Kamatani *Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. yoichiro.kamatani@riken.jp.ORCID http://orcid.org/0000-0001-8748-5597
Funding
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MDiscovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MFunctionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5MMedical Research Council MR/R013926/1NHGRI NIH HHS T32 HG002295NHGRI NIH HHS U01 HG009379NIAMS NIH HHS R01 AR063759
Abstract
The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals across 42 diseases. We detected 320 independent signals in 276 loci for 27 diseases, with 25 novel loci (P < 9.58 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyCohort StudiesFemaleGenetic VariationHumansInheritance PatternsJapanMaleSex FactorsTranscription FactorsTranscription Factors
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