ArticleScientific reports2020
Anodal block permits directional vagus nerve stimulation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 55 citations in OpenAlex.
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.iScience · 2026Article
- Asymmetric tripolar nerve cuff electrode designs for optimizing anodal block of myelinated fibers.Biomedical engineering online · 2026Article
- Modulated high-frequency stimulation enables precisely timed, selective nerve block.Scientific reports · 2026Article
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.Nature communications · 2025Article
- Acute Cervical Vagus Nerve Stimulation Modulates Gastric Slow Waves in the Distal Rat Stomach.Neurogastroenterology and motility · 2025Article
- Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.Bioelectronic medicine · 2025Article
- The Effects of Craniofacial Muscle Contractions on the Formerly Vagus Nerve Somatosensory Evoked Potentials.Cureus · 2025Article
- Minimally invasive, wide-field two-photon imaging of the brainstem at cellular resolution.Cell reports methods · 2025Article
- Bioelectronic Therapeutics: A Revolutionary Medical Practice in Health Care.Bioelectricity · 2025Review
- Vagal sensory neuron-derived FGF3 controls insulin secretion.Developmental cell · 2025Article
- Bioelectronic Medicines-A Novel Approach of Therapeutics in Current Epoch.Current pharmaceutical design · 2025Review
- Impaired inhibitory reno-renal reflex responses in chronic kidney disease.Frontiers in physiology · 2025Article
- The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol.Frontiers in neuroscience · 2025Article
- Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre- and postsynaptic effects in the nucleus tractus solitarii.The Journal of physiology · 2024Article
- Importance of cardiac-synchronized vagus nerve stimulation parameters on the provoked chronotropic response for different levels of cardiac innervation.Frontiers in physiology · 2024Article
- Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control.AIChE journal. American Institute of Chemical Engineers · 2023Article
- Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect.Journal of neural engineering · 2023Article
- Vagus Nerve Stimulation and Its Cardioprotective Abilities: A Systematic Review.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for afferent and efferent fiber activation by VNS: stimulus-elicited change in breathing rate (ΔBR) and heart rate (ΔHR), respectively. Bipolar VNS trains of both polarities elicited mixed ΔHR and ΔBR responses. Cathode cephalad polarity caused an afferent pattern of responses (relatively stronger ΔBR) whereas cathode caudad caused an efferent pattern (stronger ΔHR). Additionally, left VNS elicited a greater afferent and right VNS a greater efferent response. By analyzing stimulus-evoked compound nerve potentials, we confirmed that such polarity differences in functional responses to VNS can be explained by ABL of A- and B-fiber activation. We conclude that ABL is a mechanism that can be leveraged for directional VNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.