ArticleScientific reports2020
A Unique Mouse Model of Early Life Exercise Enables Hippocampal Memory and Synaptic Plasticity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- Physical activity stimulates neurogenesis via sensory neuron activity in postembryonic zebrafish.iScience · 2026Article
- Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Increasing the health span: unique role for exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- Train and Reprogram Your Brain: Effects of Physical Exercise at Different Stages of Life on Brain Functions Saved in Epigenetic Modifications.International journal of molecular sciences · 2024Review
- Treadmill exercise prevents recognition memory impairment in VD rat model and enhancement of hippocampal structural synaptic plasticity.Brain and behavior · 2024Article
- Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring.Scientific reports · 2024Article
- Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice.Nature communications · 2024Article
- Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory.Scientific reports · 2024Article
- Voluntary running wheel exercise induces cognitive improvement post traumatic brain injury in mouse model through redressing aberrant excitation regulated by voltage-gated sodium channels 1.1, 1.3, and 1.6.Experimental brain research · 2024Article
- Early-life exercise primes the murine neural epigenome to facilitate gene expression and hippocampal memory consolidation.Communications biology · 2023Article
- Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery.Developmental neuroscience · 2023Review
- Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model.Molecular neurobiology · 2023Article
- Walking, Running, Swimming: An Analysis of the Effects of Land and Water Aerobic Exercises on Cognitive Functions and Neural Substrates.International journal of environmental research and public health · 2022Review
- Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice.Neurobiology of learning and memory · 2022Article
- Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice.npj aging · 2022Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- An Improved Method for Individual Tracking of Voluntary Wheel Running in Pair-housed Juvenile Mice.Bio-protocol · 2021Article
- Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Physical exercise is a powerful modulator of learning and memory. Mechanisms underlying the cognitive benefits of exercise are well documented in adult rodents. Exercise studies targeting postnatal periods of hippocampal maturation (specifically targeting periods of synaptic reorganization and plasticity) are lacking. We characterize a model of early-life exercise (ELE) in male and female mice designed with the goal of identifying critical periods by which exercise may have a lasting impact on hippocampal memory and synaptic plasticity. Mice freely accessed a running wheel during three postnatal periods: the 4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.