ArticleNature communications2020
Animal biosynthesis of complex polyketides in a photosynthetic partnership.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Draft hybrid genome assembly of the photosynthetic sacoglossan Elysia crispata provides insights into sacoglossan biology.BMC genomics · 2026Article
- Placidenes G-J, Bioactive γ-Pyrone Derivatives From the Marine Mollusk Placida dendritica.Chemistry & biodiversity · 2026Article
- Osmolytes vs. Anabolic Reserves: Contrasting Gonadal Metabolomes in Two Sympatric Mediterranean Sea Urchins.Metabolites · 2025Article
- The enzyme kinetics of branched-chain fatty acid synthesis of metazoan fatty acid synthase.Protein science : a publication of the Protein Society · 2025Article
- An endosymbiotic origin of the crimson pigment from the lac insect.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Habitat shapes the lipidome of the tropical photosynthetic sea slugMarine life science & technology · 2025Article
- The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Diet and chemical defenses of the Sonoran Desert toad.PloS one · 2025Article
- Defensive polyketides produced by an abundant gastropod are candidate keystone molecules in estuarine ecology.Science advances · 2024Article
- Chromosome-level genome assembly of the sacoglossan sea slug Elysia timida (Risso, 1818).BMC genomics · 2024Article
- Antimicrobial, Antioxidant and Anti-Inflammatory Activities of the Mucus of the Tropical Sea SlugMolecules (Basel, Switzerland) · 2024Article
- Azooxanthellate Palythoa (Cnidaria: Anthozoa) Genomes Reveal Toxin-related Gene Clusters and Loss of Neuronal Genes in Hexacorals.Genome biology and evolution · 2024Article
- Contribution of pks+Microorganisms · 2024Review
- A cryptic radiation of Caribbean sea slugs revealed by integrative analysis:Zoological journal of the Linnean Society · 2024Article
- The polyketide to fatty acid transition in the evolution of animal lipid metabolism.Nature communications · 2024Article
- Optical Properties of Body Mucus Secreted from Coral Reef Sea Slugs: Measurement of Refractive Indices and Relative Absorption Spectra.Zoological studies · 2024Article
- A reference genome for the long-term kleptoplast-retaining sea slug Elysia crispata morphotype clarki.G3 (Bethesda, Md.) · 2023Article
- Animal FAS-like polyketide synthases produce diverse polypropionates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ocellatuspyrones A‒G, new antibacterial polypropionates from the Chinese molluskMarine life science & technology · 2023Article
- Enzymology of assembly line synthesis by modular polyketide synthases.Nature chemical biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The purified sacogolassan protein EcPKS1 uses only methylmalonyl-CoA as a substrate, otherwise unknown in animal lipid metabolism. Sacoglossans are sea slugs, some of which eat algae, digesting the cells but maintaining functional chloroplasts. Here, we provide evidence that polyketides support this unusual photosynthetic partnership. The FAS-like PKS family represents an uncharacterized branch of polyketide and fatty acid metabolism, encoding a large diversity of biomedically relevant animal enzymes and chemicals awaiting discovery. The biochemical characterization of an intact animal polyketide biosynthetic enzyme opens the door to understanding the immense untapped metabolic potential of metazoans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.