Evidence map›Paper›PMID 32513872›Full record

ArticleThe Journal of biological chemistry2020

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination.

Hae-Eun Kang, Jifeng Bian, Sarah J Kane, Sehun Kim, Vanessa Selwyn, Jenna Crowell, Jason C Bartz, Glenn C Telling

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Propagation of distinct CWD prion strains during peripheral and intracerebral challenges of gene-targeted mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hae-Eun KangPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
Jifeng BianPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.ORCID 0000-0001-6838-9938
Sarah J KanePrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.ORCID 0000-0002-6072-5682
Sehun KimPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
Vanessa SelwynPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
Jenna CrowellPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
Jason C BartzDepartment of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska.ORCID 0000-0003-4081-7886
Glenn C TellingPrion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado glenn.telling@colostate.edu.ORCID 0000-0002-6294-1805
Colorado State University · USCHI Health Creighton University Medical Center - Bergan Mercy · US

Funding

TRANSGENETIC STUDIES OF PRION DISEASE IN CERVIDSR01NS040334 · NINDS · UNIVERSITY OF KENTUCKY · PI TELLING, GLENN C · 2000 to 2014
$5.6M
Mechanisms of prion strain selectionR01NS052609 · NINDS · CREIGHTON UNIVERSITY · PI BARTZ, JASON C · 2006 to 2015
$3.2M
Characterizing the strain and host range properties of prions causing emergent forms of chronic wasting diseaseR01NS109376 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2018 to 2022
$2.4M
Mechanisms of prion strain dynamicsR01NS103763 · NINDS · CREIGHTON UNIVERSITY · PI BARTZ, JASON C · 2018 to 2022
$1.9M
NINDS NIH HHS R01 NS040334NINDS NIH HHS R01 NS103763NINDS NIH HHS R01 NS109376
6 · The paper itself

Abstract

The causative factors underlying conformational conversion of cellular prion protein (PrP

Indexed as

AnimalsAntibodies, Monoclonal, Murine-DerivedCell LineEpitopesGlycosylationPrPC ProteinsRabbitsAntibodies, Monoclonal, Murine-DerivedEpitopesPrPC Proteinsbovine spongiform encephalopathychronic wasting diseaseCreutzfeldt-Jakob diseasemonoclonal antibodyneurodegenerationN-linked glycosylationPRC7prionprion diseaseprionsprion strainsprotein misfolding

Identifiers

PMID32513872
PMCPMC7383396
OpenAlexW3033006668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.