Evidence map›Paper›PMID 32513870›Full record

ArticleThe Journal of biological chemistry2020

Two components of DNA replication-dependent LexA cleavage.

Kamila K Myka, Kenneth J Marians

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Generation and Repair of Postreplication Gaps in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  4. Article
  5. Smc5/6 Complex Promotes Rad3Molecular and cellular biology · 2022
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kamila K MykaMolecular Biology Program, Sloan Kettering Institute Memorial Sloan Kettering Cancer Center, New York, New York USA.ORCID 0000-0002-6122-2817
Kenneth J MariansMolecular Biology Program, Sloan Kettering Institute Memorial Sloan Kettering Cancer Center, New York, New York USA kmarians@sloankettering.edu.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanisms of DNA Replication, Chromosome Compaction, and Chromosome UnlinkingR35GM126907 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI KENNETH J MARIANS · 2018 to 2026
$8.8M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM126907
6 · The paper itself

Abstract

Induction of the SOS response, a cellular system triggered by DNA damage in bacteria, depends on DNA replication for the generation of the SOS signal, ssDNA. RecA binds to ssDNA, forming filaments that stimulate proteolytic cleavage of the LexA transcriptional repressor, allowing expression of > 40 gene products involved in DNA repair and cell cycle regulation. Here, using a DNA replication system reconstituted

Indexed as

DNA ReplicationProteolysisBacterial ProteinsDNA, BacterialDNA-Binding ProteinsDNA, Single-StrandedEscherichia coliEscherichia coli ProteinsLexA Repressor ProteinRec A RecombinasesSerine EndopeptidasesBacterial ProteinsDNA, BacterialDNA-Binding ProteinsDNA, Single-StrandedEscherichia coli ProteinsLexA Repressor ProteinrecA protein, E coliRec A RecombinasesrecF protein, E coliSerine EndopeptidasesDNA damage responseDNA replicationE. colienzyme degradationEscherichia coli (E. coli)gene regulationLexAproteolytic cleavagesingle-stranded DNASOS response

Identifiers

PMID32513870
PMCPMC7383369
OpenAlexW3033789989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.