Evidence map›Paper›PMID 32513868›Full record

ArticleThe Journal of biological chemistry2020

The ER-associated protease Ste24 prevents N-terminal signal peptide-independent translocation into the endoplasmic reticulum in

Akira Hosomi, Kazuko Iida, Toshihiko Cho, Hidetoshi Iida, Masashi Kaneko, Tadashi Suzuki

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Clearing Traffic Jams During Protein Translocation Across Membranes.Frontiers in cell and developmental biology · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Akira HosomiDepartment of Agriculture, Graduate School of Science and Technology, Shinshu University, Kamiina, Nagano, Japan tsuzuki_gm@riken.jp ahosomi@shinshu-u.ac.jp.
Kazuko IidaLaboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan.
Toshihiko ChoDepartment of Biology, Tokyo Gakugei University, Koganei, Tokyo, Japan.
Hidetoshi IidaDepartment of Biology, Tokyo Gakugei University, Koganei, Tokyo, Japan.
Masashi KanekoDepartment of Agriculture, Graduate School of Science and Technology, Shinshu University, Kamiina, Nagano, Japan.
Tadashi SuzukiGlycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan tsuzuki_gm@riken.jp ahosomi@shinshu-u.ac.jp.
Shinshu University · JPTokyo Gakugei University · JPRIKEN · JPTokyo Metropolitan Institute of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble proteins destined for the secretory pathway contain an N-terminal signal peptide that induces their translocation into the endoplasmic reticulum (ER). The importance of N-terminal signal peptides for ER translocation has been extensively examined over the past few decades. However, in the budding yeast

Indexed as

Endoplasmic ReticulumMembrane GlycoproteinsMembrane ProteinsMetalloendopeptidasesProtein Sorting SignalsProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSEC Translocation ChannelsMembrane GlycoproteinsMembrane ProteinsMetalloendopeptidasesProtein Sorting SignalsSaccharomyces cerevisiae ProteinsSEC61 protein, S cerevisiaeSEC66 protein, S cerevisiaeSEC72 protein, S cerevisiaeSEC Translocation ChannelsSTE24 protein, S cerevisiaecell biologyendoplasmic reticulumERglycosylationmetalloendopeptidaseN-glycosylationprotein translocationRme1secretory pathwaysignal peptideSpc2Ste24yeast

Identifiers

PMID32513868
PMCPMC7383372
OpenAlexW3033451058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.