Evidence map›Paper›PMID 32513855›Full record

ArticleInfection and immunity2020

Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae.

Francesca L Short, Gianna Di Sario, Nathalie T Reichmann, Colin Kleanthous, Julian Parkhill, Peter W Taylor

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
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  3. Hypermucoviscosity inJournal of bacteriology · 2026
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  5. Differential virulence potential of different clades of multidrug-resistantmedRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Connections betweenInfection and immunity · 2026
    Article
  8. Article
  9. Article
  10. Divergent roles for complement components C3 and C4 in controllingbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. O-antigen polysaccharides inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  16. mBio · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Virulence · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Francesca L ShortWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom fs13@sanger.ac.uk.ORCID 0000-0002-0025-4858
Gianna Di SarioSchool of Pharmacy, University College London, London, United Kingdom.ORCID 0000-0003-1919-6050
Nathalie T ReichmannDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1003-6376
Colin KleanthousDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Julian ParkhillWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.ORCID 0000-0002-7069-5958
Peter W TaylorSchool of Pharmacy, University College London, London, United Kingdom.
University College London · GBUniversity of Cambridge · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/R009937/1Wellcome Trust 106063/A/14/ZWellcome Trust 206194
6 · The paper itself

Abstract

The serum complement system is a first line of defense against bacterial invaders. Resistance to killing by serum enhances the capacity of

Indexed as

Genes, BacterialImmune EvasionBacterial Outer Membrane ProteinsBlood Bactericidal ActivityCarboxy-LyasesComplement C3bComplement Membrane Attack ComplexDNA Transposable ElementsGene Expression ProfilingGene Expression Regulation, BacterialGene LibraryHumansKlebsiella InfectionsKlebsiella pneumoniaeMutationPeptide Elongation FactorsBacterial Outer Membrane ProteinsCarboxy-LyasesComplement C3bComplement Membrane Attack ComplexDNA Transposable ElementsPeptide Elongation Factorscapsulecomplement resistancefunctional genomicsKlebsiellaserum resistanceTn-SeqTraDIStransposon insertion sequencing

Identifiers

PMID32513855
PMCPMC7375759
OpenAlexW3033561057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.