Evidence map›Paper›PMID 32513737›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network.

Matei Bolborea, Eric Pollatzek, Heather Benford, Tamara Sotelo-Hitschfeld, Nicholas Dale

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
  3. Article
  4. Article
  5. Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026
    Review
  6. Article
  7. Review
  8. Perspective: rheostasis revisited-hibernation and tanycytes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Calcium Imaging in Hypothalamic Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  13. Hypothalamic neuronal-glial crosstalk in metabolic disease.npj metabolic health and disease · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matei BolboreaSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom m.bolborea@warwick.ac.uk n.e.dale@warwick.ac.uk.ORCID 0000-0003-2313-2770
Eric PollatzekSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.
Heather BenfordSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.
Tamara Sotelo-HitschfeldSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0001-9094-9073
Nicholas DaleSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom m.bolborea@warwick.ac.uk n.e.dale@warwick.ac.uk.ORCID 0000-0003-2196-2949
University of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M022692/1Medical Research Council MC_PC_15070Medical Research Council MR/J003786/1
6 · The paper itself

Abstract

Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca

Indexed as

Agouti-Related ProteinAnimalsAppetiteArcuate Nucleus of HypothalamusChannelrhodopsinsEnergy MetabolismEpendymoglial CellsFeeding BehaviorFemaleGenes, ReporterHyperphagiaInjections, IntraventricularMaleMiceMice, TransgenicModels, AnimalAgouti-Related ProteinAgrp protein, mouseChannelrhodopsinsNeuropeptide YPro-Opiomelanocortinarcuate nucleusATPfood intakehypothalamustanycyte

Identifiers

PMID32513737
PMCPMC7322081
OpenAlexW3033043430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.