Evidence map›Paper›PMID 32513671›Full record

ReviewCold Spring Harbor perspectives in medicine2022

Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States.

Jose Rodriguez-Romaguera, Vijay M K Namboodiri, Marcus L Basiri, Alice M Stamatakis, Garret D Stuber

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jose Rodriguez-RomagueraDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Vijay M K NamboodiriCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine & Department of Pharmacology, University of Washington, Seattle, Washington 98195-6410, USA.
Marcus L BasiriNeuroscience Curriculum, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Alice M StamatakisNeuroscience Curriculum, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine & Department of Pharmacology, University of Washington, Seattle, Washington 98195-6410, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Neural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5M
Lateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0M
Neural encoding of associative learning by orbitofrontal cortex circuitsR00MH118422 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI K NAMBOODIRI, VIJAY MOHAN · 2020 to 2022
$747k
Neural encoding of associative learning by orbitofrontal cortex circuitsK99MH118422 · NIMH · UNIVERSITY OF WASHINGTON · PI K NAMBOODIRI, VIJAY MOHAN · 2019 to 2020
$141k
Functional dynamics of BNST neurons during distinct anxiety statesF32MH113327 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RODRIGUEZ-ROMAGUERA, JOSE · 2017 to 2019
$128k
Encoding Precise Behavioral Features of Anxiety by Cortico-BNST EnsemblesF30MH115693 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI UNG, RANDALL · 2018 to 2019
$72k
NIDA NIH HHS R01 DA038168NIDA NIH HHS R37 DA032750NIGMS NIH HHS T32 GM008719NIMH NIH HHS F30 MH115693NIMH NIH HHS F32 MH113327NIMH NIH HHS K99 MH118422NIMH NIH HHS R00 MH118422
6 · The paper itself

Abstract

Motivational states are regulated by complex networks across brain regions that are composed of genetically and functionally distinct neuronal populations. Disruption within these neural circuits leads to aberrant motivational states and are thought to be the root cause of psychiatric disorders related to reward processing and addiction. Critical technological advances in the field have revolutionized the study of neural systems by allowing the use of optical strategies to precisely control and visualize neural activity within genetically identified neural populations in the brain. This review will provide a brief introduction into the history of how technological advances in single-cell strategies have been applied to elucidate the neural circuits that underlie aberrant motivational states that often lead to dysfunction in reward processing and addiction.

Indexed as

Mental DisordersOptogeneticsBrainHumansNeuronsReward

Identifiers

PMID32513671
PMCPMC7799172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.