ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Estimating Brain Connectivity With Diffusion-Weighted Magnetic Resonance Imaging: Promise and Peril.
Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Multi-compartment Myelin Streamline Decomposition reveals tract-specific and global brain network myelination in Multiple Sclerosis.Neuroimage. Reports · 2026Article
- Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients.bioRxiv : the preprint server for biology · 2026Article
- Visualization of small vibrations inside an MRI scanner using video motion amplification.Medical physics · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Depicting Coupling Between Cortical Morphology and Functional Networks in Major Depressive Disorder.Depression and anxiety · 2025Article
- A biophysically constrained brain connectivity model based on stimulation-evoked potentials.Journal of neuroscience methods · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Diffusion tensor imaging in cerebral small vessel disease applications: opportunities and challenges.Frontiers in neuroscience · 2024Review
- A biophysically constrained brain connectivity model based on stimulation-evoked potentials.bioRxiv : the preprint server for biology · 2023Article
- Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective.International journal of molecular sciences · 2023Review
- PET imaging of animal models with depressive-like phenotypes.European journal of nuclear medicine and molecular imaging · 2023Review
- versaFlow: a versatile pipeline for resolution adapted diffusion MRI processing and its application to studying the variability of the PRIME-DE database.Frontiers in neuroinformatics · 2023Article
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
- A taxonomy of the brain's white matter: twenty-one major tracts for the 21st century.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Structural, Functional and Neurochemical Cortical Brain Changes Associated with Chronic Low Back Pain.Tomography (Ann Arbor, Mich.) · 2022Review
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Abstract
Diffusion-weighted magnetic resonance imaging (dMRI) is a popular tool for noninvasively assessing properties of white matter in the brain. Among other uses, dMRI data can be used to produce estimates of anatomical connectivity on the basis of tractography. However, direct comparisons of anatomical connectivity as estimated through invasive neural tract-tracing experiments and dMRI-derived connectivity have shown only a moderate relationship in nonhuman primate (particularly macaque) studies. Tractography is plagued by known problems associated with resolution, crossing fibers, and curving fibers, among others. These problems lead to deficits in both sensitivity and specificity, which trade off with each other in multiple datasets. Although not yet examined quantitatively, there is reason to believe that some large white matter bundles, those with more topographic organization, may produce more accurate results than others. Moving forward, sophisticated analytical approaches and anatomical constraints may improve tractography accuracy. However, broadly speaking, dMRI-derived estimates of brain connectivity should be approached with caution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.