ArticleBMC medicine2020
Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026Article
- BMI-genome interactions regulate global gene expression with emphasis in brain and gut.Cell genomics · 2026Article
- Dementia risk by metabolic health and obesity in two prospective cohorts.BMC medicine · 2026Article
- Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry.Aging cell · 2025Article
- Age of menopause and dementia risk in 10,832 women from the Swedish Twin Registry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Identification of the Critical Life-Stage of Obesity Contributing to Brain Functional Networks.CNS neuroscience & therapeutics · 2025Article
- A lifespan perspective on cognitive reserve and risk for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state.Diabetes, obesity & metabolism · 2025Article
- Relationship between obesity indices and cognitive function in Japanese men: A cross-sectional study.PloS one · 2025Article
- Associations of body habitus and its changes with incident dementia in older adults.Journal of the American Geriatrics Society · 2024Article
- Dementia and mortality in older adults: A twin study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- How Modifiable Are Modifiable Dementia Risk Factors? A Framework for Considering the Modifiability of Dementia Risk Factors.The journal of prevention of Alzheimer's disease · 2024Review
- Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility.Przeglad gastroenterologiczny · 2024Article
- Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells.Epigenetics · 2023Article
- Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings.Brain : a journal of neurology · 2023Article
- Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels.European journal of epidemiology · 2022Article
- Circulating miR-181a as a novel potential plasma biomarker for multimorbidity burden in the older population.BMC geriatrics · 2022Article
- Education as a moderator of middle-age cardiovascular risk factor-old-age cognition relationships: testing cognitive reserve hypothesis in epidemiological study.Age and ageing · 2022Article
- Association of Cardiovascular Health Metrics with Dementia in Rural Chinese Older Adults: A Population-Based Study.Clinical interventions in aging · 2022Article
- Association between change in handgrip strength and cognitive function in Korean adults: a longitudinal panel study.BMC geriatrics · 2021Article
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5 authors.
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Abstract
backgroundWhile a high body mass index (BMI) in midlife is associated with higher risk of dementia, high BMI in late-life may be associated with lower risk. This study combined genetic designs with longitudinal data to achieve a better understanding of this paradox.
methodsWe used longitudinal data from 22,156 individuals in the Swedish Twin Registry (STR) and 25,698 from the Health and Retirement Study (HRS). The STR sample had information about BMI from early adulthood through late-life, and the HRS sample from age 50 through late-life. Survival analysis was applied to investigate age-specific associations between BMI and dementia risk. To examine if the associations are influenced by genetic susceptibility to higher BMI, an interaction between BMI and a polygenic score for BMI (PGS
resultsAt age 35-49, 5 units higher BMI was associated with 15% (95% CI 7-24%) higher risk of dementia in the STR. There was a significant interaction (p = 0.04) between BMI and the PGS
conclusionsNot only does the association between BMI and dementia differ depending on age at BMI measurement, but also the effect of genetic influences. In STR, the associations were only present among those with a BMI in opposite direction of their genetic predisposition, indicating that the association between BMI and dementia across the life course might be driven by environmental factors and hence likely modifiable.
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