ReviewCritical care (London, England)2020
Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
Review in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pooled it
- Dose-Finding of Alfentanil for Hysteroscopy Under Remimazolam Sedation in Obese and Normal-Weight Patients: An Up-and-Down Trial.Drug design, development and therapy · 2026Trial
- Ketamine's impact on mood after day-case surgery and its relation to obesity: a randomised controlled trial in women undergoing fractional curettage.BMC women's health · 2025Trial
- Efficacy and safety of ciprofol for gastroscopy in patients with obesity: a randomised clinical controlled trial using different weight-based dosing scales.BMC anesthesiology · 2025Trial
- Association of Obesity With Sedative Dosing, Sedative Response, and Clinical Outcomes in Mechanically Ventilated Critically Ill Children.Critical care explorations · 2025Trial
- Key principles for rehabilitation of critically ill patients with obesity.Intensive care medicine · 2026Review
- ECMO for patients with obesity: evidence and practice.Intensive care medicine · 2026Review
- Airway management in critically ill patients with obesity.Intensive care medicine · 2026Review
- A national benchmarking survey to explore the use of dose error reduction software in adult intensive care units (ICUs).Journal of the Intensive Care Society · 2026Article
- Post-intubation sedation in the emergency department: A scoping review.The American journal of emergency medicine · 2026Article
- Pediatric Difficult Airway Simulation Day.Journal of education & teaching in emergency medicine · 2026Article
- Modeling drug retention as memory effects in obese patients using fractional and augmented models.Scientific reports · 2025Article
- Article
- Safety and efficacy of remifentanil in patients undergoing bariatric and metabolic surgeries - A systematic review.Indian journal of anaesthesia · 2025Article
- Population pharmacokinetic analysis of remimazolam after continuous infusion for sedation in critically ill patients.Frontiers in pharmacology · 2025Article
- Obesity: a challenge for emergency medical teams-a narrative review.Frontiers in public health · 2025Review
- Efficacy and Safety of Ciprofol for Anesthesia in Painless Colonoscopy with Varying Body Mass Indices Patients: A Prospective, Single-Center, Observational Study.Drug design, development and therapy · 2025Observational
- Non-Opioid Analgesics and Adjuvants after Surgery in Adults with Obesity: Systematic Review with Network Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Physical and respiratory therapy in the critically ill patient with obesity: a narrative review.Frontiers in medicine · 2024Review
- Comparison of Fat-Free Mass and Ideal Body Weight Scalar for Anesthetic Induction Dose of Propofol in Patients with Morbid Obesity: A Double-Blind, Randomized Clinical Trial.Anesthesiology and pain medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Practice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.