ArticleRespiratory research2020
Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients.
Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Occupational exposure to toxic particles and risk of pulmonary sarcoidosis: a systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- Occupational exposures and sarcoidosis: a rapid review of the evidence.Occupational medicine (Oxford, England) · 2024Pooled it
- Systemic chronic beryllium disease: beyond lung disease.Occupational and environmental medicine · 2026Article
- Diagnosis and treatment of sarcoidosis based on immunological etiology and mechanisms.Frontiers in medicine · 2026Review
- Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Sarcoidosis Induced by Metal Particles From a Left Elbow Prosthesis.Kidney medicine · 2025Article
- Silicosarcoidosis: Histologic and Clinical Features of an Occupational Granulomatous Disease.American journal of industrial medicine · 2025Article
- Sarcoidosis: molecular mechanisms and therapeutic strategies.Molecular biomedicine · 2025Review
- A framework for exclusion of alternative diagnoses in sarcoidosis.Journal of autoimmunity · 2024Review
- Sarcoidosis: a general overview.Advances in rheumatology (London, England) · 2024Review
- Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study.Occupational and environmental medicine · 2024Article
- Review
- Lung fibrosis in sarcoidosis. Is there a place for antifibrotics?Frontiers in pharmacology · 2024Review
- Clinical Manifestations and Management of Fibrotic Pulmonary Sarcoidosis.Journal of clinical medicine · 2023Review
- Methods to Assess Proliferation of Stimulated Human Lymphocytes In Vitro: A Narrative Review.Cells · 2023Review
- Pulmonary sarcoid-like granulomatosis induced by aluminum dust: A case report and literature review.Frontiers in medicine · 2023Article
- Sarcoid-like Lung Disease as a Reaction to Silica from Exposure to Bentonite Cat Litter Complicated by End-Stage Renal Failure-A Case Report.International journal of environmental research and public health · 2022Article
- The Role ofMicroorganisms · 2022Review
- Sarcoid-like Granulomatous Lung Disease with Subacute Progression in Silicosis.Internal medicine (Tokyo, Japan) · 2022Article
- The position of geochemical variables as causal co-factors of diseases of unknown aetiology.SN applied sciences · 2022Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundInvolvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immunological reaction has not been studied before in a group of sarcoidosis patients and non-sarcoidosis controls.
methodsIn 256 sarcoidosis patients and 73 control patients with obstructive sleep apnea, exposure to metal and silica was assessed using a questionnaire consisting of a complete occupational history subsequently linked to job-exposure matrices. Next, immunoreactivity to aluminium, beryllium, zirconium and silica was determined in 33 sarcoidosis and 19 control patients using a lymphocyte proliferation test.
resultsIn sarcoidosis, 83 out 256 patients (32.4%) had occupational exposure to metals or silica, compared to 24.7% in the control group (p = 0.21). A significantly higher percentage of the sarcoidosis patients tested showed immunoreactivity to metals or silica compared to the control group (21.2 and 0% respectively, p = 0.039).
conclusionsImmunoreactivity to silica and metals was only found in sarcoidosis patients, supporting the hypothesis that these antigens may be involved in the pathogenesis of a distinct subgroup of sarcoidosis patients. This indicates that when searching for causative agents in sarcoidosis patients, besides beryllium, also zirconium, aluminium and silica deserve clinical investigation.
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Registered trials
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