ReviewAnnual review of chemical and biomolecular engineering2020
How Do Cells Adapt? Stories Told in Landscapes.
Review in Annual review of chemical and biomolecular engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Flip Flop-Associated Growth and Division of Synthetic Cells.ACS nano · 2026Article
- The challenge of distinguishing living from non-living entities.Theory in biosciences = Theorie in den Biowissenschaften · 2026Review
- Environmental Regulation and Gene-by-Environment Interaction InfluencebioRxiv : the preprint server for biology · 2026Article
- Foundations of cognitive systems: exploring the architecture of mind and intelligence.Cognitive processing · 2026Review
- Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440.Microbial biotechnology · 2025Article
- Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks.iScience · 2025Article
- PyCoM: a python library for large-scale analysis of residue-residue coevolution data.Bioinformatics (Oxford, England) · 2024Article
- Article
- Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Is cancer an intelligent species?Cancer metastasis reviews · 2023Review
- Evidence of cancer-linked rodent zoonoses from biophysical genomic variations.Scientific reports · 2023Article
- Article
- Article
- Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers.Biochemistry and biophysics reports · 2022Article
- Quantification of adaptive forces on SNP rs1010211 due to viral zoonotic pathogens.Journal of biological physics · 2022Article
- Article
- Review
- Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma.iScience · 2021Article
- The Protein Folding Problem: The Role of Theory.Journal of molecular biology · 2021Review
- Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-genetic Heterogeneity in Prostate Cancer Cells.Entropy (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cells adapt to changing environments. Perturb a cell and it returns to a point of homeostasis. Perturb a population and it evolves toward a fitness peak. We review quantitative models of the forces of adaptation and their visualizations on landscapes. While some adaptations result from single mutations or few-gene effects, others are more cooperative, more delocalized in the genome, and more universal and physical. For example, homeostasis and evolution depend on protein folding and aggregation, energy and protein production, protein diffusion, molecular motor speeds and efficiencies, and protein expression levels. Models provide a way to learn about the fitness of cells and cell populations by making and testing hypotheses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.