Evidence map›Paper›PMID 32512924›Full record

Observational studyBiomolecules2020

Endothelial Dysfunction May Link Interatrial Septal Abnormalities and MTHFR-Inherited Defects to Cryptogenic Stroke Predisposition.

Luca Sgarra, Alessandro Santo Bortone, Maria Assunta Potenza, Carmela Nacci, Maria Antonietta De Salvia, Tommaso Acquaviva, Emanuela De Cillis, Marco Matteo Ciccone, Massimo Grimaldi, Monica Montagnani

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Luca SgarraDepartment of Biomedical Sciences and Human Oncology-Section of Pharmacology, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Alessandro Santo BortoneDepartment of Emergency and Organ Transplantation-Section of Cardiovascular Diseases, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Maria Assunta PotenzaDepartment of Biomedical Sciences and Human Oncology-Section of Pharmacology, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Carmela NacciDepartment of Biomedical Sciences and Human Oncology-Section of Pharmacology, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Maria Antonietta De SalviaDepartment of Biomedical Sciences and Human Oncology-Section of Pharmacology, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Tommaso AcquavivaDepartment of Emergency and Organ Transplantation-Section of Cardiovascular Diseases, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Emanuela De CillisDepartment of Emergency and Organ Transplantation-Section of Cardiovascular Diseases, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Marco Matteo CicconeDepartment of Emergency and Organ Transplantation-Section of Cardiovascular Diseases, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
Massimo GrimaldiGeneral Hospital "F. Miulli" Acquaviva delle Fonti, 70021 Bari, Italy.
Monica MontagnaniDepartment of Biomedical Sciences and Human Oncology-Section of Pharmacology, Medical School, University of Bari "Aldo Moro", 70124 Bari, Italy.
University of Bari Aldo Moro · ITOspedale Generale Regionale Francesco Miulli · IT

Funding

Universita degli Studi di Bari Aldo Moro CUP H96J15001610005Universita degli Studi di Bari Aldo Moro UPB:DIMO 102200201
6 · The paper itself

Abstract

We explored the significance of the L-Arginine/asymmetric dimethylarginine (L-Arg/ADMA) ratio as a biomarker of endothelial dysfunction in stroke patients. To this aim, we evaluated the correlation, in terms of severity, between the degree of endothelial dysfunction (by L-Arg/ADMA ratio), the methylene tetrahydrofolate reductase (MTHFR) genotype, and the interatrial septum (IAS) phenotype in subject with a history of stroke.

Indexed as

AdultAtrial SeptumEndothelium, VascularGenotypeHumansIschemic StrokeMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedRetrospective StudiesMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humancryptogenic strokeendothelial dysfunctionL-Arg/ADMAMTHFRPFO

Identifiers

PMID32512924
PMCPMC7355772
OpenAlexW3033255566

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.