Evidence map›Paper›PMID 32512716›Full record

Observational studyToxins2020

Exoenzyme Y Contributes to End-Organ Dysfunction Caused by

Brant M Wagener, Naseem Anjum, Sarah C Christiaans, Morgan E Banks, Jordan C Parker, Adam T Threet, Rashidra R Walker, Kayla D Isbell, Stephen A Moser, Troy Stevens and 7 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

  1. HDAC6 inhibition reducesInfection and immunity · 2026
    Article
  2. Review
  3. Molecular Mechanisms Underlying the Pathogenicity ofMedicina (Kaunas, Lithuania) · 2026
    Review
  4. Article
  5. Biofilm Formation ofMicroorganisms · 2025
    Review
  6. Article
  7. ThePathogens (Basel, Switzerland) · 2024
    Article
  8. Does Every Strain ofPathogens (Basel, Switzerland) · 2024
    Article
  9. American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  10. Article
  11. cUMP elicits interendothelial gap formation duringAmerican journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  12. Review
  13. Interesting Cytokine Profile Caused by Clinical Strains ofInternational journal of microbiology · 2024
    Article
  14. Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  15. Cells · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival during Infection.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Brant M WagenerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-7889-1526
Naseem AnjumDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Sarah C ChristiaansDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Morgan E BanksDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-5934-077X
Jordan C ParkerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Adam T ThreetDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rashidra R WalkerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kayla D IsbellDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-9356-9655
Stephen A MoserDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Troy StevensCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Mikhail F AlexeyevCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Jonathon P AudiaCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Wito RichterCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Kierra S HardyDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Lina Abou SalehCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Charity MorganDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jean-François PittetDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USUniversity of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6M
Store-operated calcium entry: lung endothelial permeabilityR37HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2010 to 2019
$3.9M
Store Operated Calcium Entry: Lung Endothelial PermeabilityR01HL060024 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 1998 to 2009
$3.0M
Training in Cell Signaling and Lung PathobiologyT32HL076125 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI RICH, THOMAS C, STEVENS, TROY · 2004 to 2018
$2.7M
Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
The Role of Sex Dimorphism in Post-TBI Bacterial PneumoniaR01GM127584 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WAGENER, BRANT M · 2018 to 2022
$1.9M
Regulation of phosphodiesterases and cAMP signaling during the host-pathogen interaction in the pulmonary endotheliumR01HL141473 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI RICHTER, WITO H · 2018 to 2021
$1.5M
NHLBI NIH HHS HL076125NHLBI NIH HHS HL118334NHLBI NIH HHS HL118334-S1NHLBI NIH HHS HL141473NHLBI NIH HHS HL60024NHLBI NIH HHS HL66299NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL118334NHLBI NIH HHS R01 HL141473NHLBI NIH HHS R37 HL060024NHLBI NIH HHS T32 HL076125NIGMS NIH HHS GM127584NIGMS NIH HHS R01 GM127584NIH Office of the Director OD010944U.S. Department of Defense W81XWH-16-1-0096
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBacterial ProteinsBacterial ToxinsCells, CulturedCritical IllnessCross InfectionFemaleGlucosyltransferasesHumansMaleMiddle AgedMultiple Organ FailurePneumonia, BacterialProspective StudiesPseudomonas aeruginosaPseudomonas InfectionsBacterial ProteinsBacterial ToxinsExoY protein, bacteriaGlucosyltransferasesVirulence FactorsamyloidExoUpneumoniatauType III secretion system

Identifiers

PMID32512716
PMCPMC7354586
OpenAlexW3033772179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.