ArticleMolecular plant pathology2020
A novel effector CfEC92 of Colletotrichum fructicola contributes to glomerella leaf spot virulence by suppressing plant defences at the early infection phase.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 49 citations in OpenAlex.
- Diversity and Host Associations of the Genus Colletotrichum in Korea.The plant pathology journal · 2026Review
- Systematic Identification and Functional Characterisation of Colletotrichum fructicola Effectors During Camellia oleifera Colonisation.Molecular plant pathology · 2026Article
- Molecular insights and integrated management of Glomerella leaf spot in apple.Horticulture research · 2026Review
- Genus-wide comparative genomics ofIMA fungus · 2026Article
- Plant Pathogenic and EndophyticMicroorganisms · 2025Review
- AScience advances · 2025Article
- Decoding Pecan's Fungal Foe: A Genomic Insight intoJournal of fungi (Basel, Switzerland) · 2025Article
- Exploring the infection strategy ofFrontiers in plant science · 2025Article
- Apple Bitter Rot: Biology, Ecology, Omics, Virulence Factors, and Management of Causal Colletotrichum Species.Molecular plant pathology · 2025Review
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- Article
- Determination of anthracnose (Colletotrichum fructicola) resistance mechanism using transcriptome analysis of resistant and susceptible pear (Pyrus pyrifolia).BMC plant biology · 2024Article
- Extracellular perception of multiple novel core effectors from the broad host-range pear anthracnose pathogenHorticulture research · 2024Article
- Genome comparisons reveal accessory genes crucial for the evolution of apple Glomerella leaf spot pathogenicity in Colletotrichum fungi.Molecular plant pathology · 2024Article
- Small secreted effector protein from Fusarium sacchari suppresses host immune response by inhibiting ScPi21-induced cell death.Molecular plant pathology · 2024Article
- A fungal CFEM-containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity.Plant biotechnology journal · 2024Article
- Transcriptome analysis ofFrontiers in plant science · 2024Article
- The mMolecular plant pathology · 2023Article
- GDSL Esterase/Lipase GELP1 Involved in the Defense of Apple Leaves againstInternational journal of molecular sciences · 2023Article
- Pectate Lyase Genes Abundantly Expressed During the Infection Regulate Morphological Development ofmSphere · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ascomycete fungus Colletotrichum fructicola causes diseases on a broad range of plant species. On susceptible cultivars of apple, it induces severe early defoliation and fruit spots, named glomerella leaf spot (GLS), but the mechanisms of pathogenicity have remained elusive. Phytopathogens exhibit small secreted effectors to advance host infection by manipulating host immune reactions. We report the identification and characterization of CfEC92, an effector required for C. fructicola virulence. CfEC92 is a Colletotrichum-specific small secreted protein that suppresses BAX-triggered cell death in Nicotiana benthamiana. Accumulation of the gene transcript was barely detectable in conidia or vegetative hyphae, but was highly up-regulated in appressoria formed during early apple leaf infection. Gene deletion mutants were not affected in vegetative growth, appressorium formation, or appressorium-mediated cellophane penetration. However, the mutants were significantly reduced in virulence toward apple leaves and fruits. Microscopic examination indicated that infection by the deletion mutants elicited elevated deposition of papillae at the penetration sites, and formation of infection vesicles and primary hyphae was retarded. Signal peptide activity, subcellular localization, and cell death-suppressive activity (without signal peptide) assays suggest that CfEC92 could be secreted and perform virulence functions inside plant cells. RNA sequencing and quantitative reverse transcription PCR results confirmed that the deletion mutants triggered elevated host defence reactions. Our results strongly support the interpretation that CfEC92 contributes to C. fructicola virulence as a plant immunity suppressor at the early infection phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.