ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Seizure onset location shapes dynamics of initiation.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Inter-seizure variability in thalamic recruitment and its implications for precision thalamic neuromodulation.Communications medicine · 2025Article
- Ictal phase-amplitude coupling as a biomarker for seizure onset zone in neocortical epilepsy.Frontiers in neurology · 2025Article
- A Nonlinear Method to Identify Seizure Dynamic Trajectory Based on Variance of Recurrence Rate in Human Epilepsy Patients Using EEG.Journal of medical signals and sensors · 2025Article
- Differentiating rhythmic high-amplitude delta with superimposed (poly) spikes from extreme delta brushes: limitations of standardized nomenclature and implications for patient management.World journal of pediatrics : WJP · 2024Review
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Network-motif delay differential analysis of brain activity during seizures.Chaos (Woodbury, N.Y.) · 2023Article
- Modular pipeline for reconstruction and localization of implanted intracranial ECoG and sEEG electrodes.PloS one · 2023Article
- Chronic intracranial EEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states.Brain communications · 2023Article
- Quantifying seizure termination patterns reveals limited pathways to seizure end.Neurobiology of disease · 2022Article
- Multiple mechanisms shape the relationship between pathway and duration of focal seizures.Brain communications · 2022Article
- Brain network dynamics codify heterogeneity in seizure evolution.Brain communications · 2022Article
- Accuracy of high-frequency oscillations recorded intraoperatively for classification of epileptogenic regions.Scientific reports · 2021Article
- Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity.NeuroImage · 2021Article
- Measuring the Coupling Direction between Neural Oscillations with Weighted Symbolic Transfer Entropy.Entropy (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIctal electrographic patterns are widely thought to reflect underlying neural mechanisms of seizures. Here we studied the degree to which seizure patterns are consistent in a given patient, relate to particular brain regions and if two candidate biomarkers (high-frequency oscillations, HFOs; infraslow activity, ISA) and network activity, as assessed with cross-frequency interactions, can discriminate between seizure types.
methodsWe analyzed temporal changes in low and high frequency oscillations recorded during seizures, as well as phase-amplitude coupling (PAC) to monitor the interactions between delta/theta and ripple/fast ripple frequency bands at seizure onset.
resultsSeizures of multiple electrographic patterns were observed in a given patient and brain region. While there was an increase in HFO rate across different electrographic patterns, there are specific relationships between types of HFO activity and onset region. Similarly, changes in PAC dynamics were more closely related to seizure onset region than they were to electrographic patterns while ISA was a poor indicator for seizure onset.
conclusionsOur findings suggest that the onset region sculpts neurodynamics at seizure initiation and that unique features of the cytoarchitecture and/or connectivity of that region play a significant role in determining seizure mechanism. SIGNIFICANCE: To learn how seizures are initiated, researchers would do well to consider other aspects of their manifestation, in addition to their electrographic patterns. Examination of onset pattern in conjunction with the interactions between different oscillatory frequencies in the context of different brain regions might be more informative and lead to more reliable clinical inference as well as novel therapeutic approaches.
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