Evidence map›Paper›PMID 32511919›Full record

ArticleJournal of the American Chemical Society2020

A Peroxodiiron(III/III) Intermediate Mediating Both

Molly J McBride, Debangsu Sil, Tai L Ng, Anne Marie Crooke, Grace E Kenney, Christina R Tysoe, Bo Zhang, Emily P Balskus, Amie K Boal, Carsten Krebs and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Article
  3. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  4. Article
  5. Article
  6. RadicalJournal of the American Chemical Society · 2026
    Article
  7. A ferritin-like diiron oxygenase BioE initiates bacterial biotin synthesis, a promising antivirulence target.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Heme Oxygenase-Like Metalloenzymes.Annual review of biochemistry · 2025
    Review
  10. Article
  11. Biochemical characterization of the self-sacrificing p-aminobenzoate synthase from Nitrosomonas europaea reveals key residues involved in selecting a Fe/Fe or Mn/Fe cofactor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  12. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Elucidation of Chalkophomycin Biosynthesis RevealsJournal of the American Chemical Society · 2024
    Article
  19. Elucidation of chalkophomycin biosynthesis revealsbioRxiv : the preprint server for biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tai L NgDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-1763-5590
Anne Marie CrookeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-1581-6104
Grace E KenneyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0002-9579-3351
Christina R TysoeORCID 0000-0003-0408-3432
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-5985-5714
J Martin BollingerORCID 0000-0003-0751-8585
Pennsylvania State University · USHarvard University · US

Funding

Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
Biocompatible Chemistry for In Vivo Metabolite ModificationDP2GM105434 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2012 to 2012
$2.5M
The biosynthesis of N-N bond-containing natural productsR01GM132564 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2020 to 2023
$1.5M
Structures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3M
NIGMS NIH HHS DP2 GM105434NIGMS NIH HHS R01 GM132564NIGMS NIH HHS R01 GM138580NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

The alkylating warhead of the pancreatic cancer drug streptozotocin (SZN) contains an

Indexed as

Bacterial ProteinsFerric CompoundsHydroxylationMetalloproteinsModels, MolecularMolecular StructureNitrosourea CompoundsStreptomycesStreptozocinBacterial ProteinsFerric CompoundsMetalloproteinsNitrosourea CompoundsStreptozocin

Identifiers

PMID32511919
PMCPMC7359745
OpenAlexW3033414899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.