Evidence map›Paper›PMID 32511726›Full record

Trial reportSleep2020

Intraindividual variability in sleep schedule: effects of an internet-based cognitive-behavioral therapy for insomnia program and its relation with symptom remission.

Kelly M Shaffer, Donald Hedeker, Charles M Morin, Karen Ingersoll, Frances Thorndike, Lee M Ritterband

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00328250 (Internet Insomnia Intervention), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00328250 phase1 / phase2completednot on this map

Internet Insomnia Intervention: Development and Feasibility

TypeinterventionalSponsorUniversity of VirginiaRan2006 to 2009Enrolled44ConditionsSleep Initiation and Maintenance DisordersArmsCognitive behavioral treatment (CBT) delivered over the Internet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Caregivers' Internet-Delivered Insomnia Intervention Engagement and Benefit: SHUTi-CARE Trial Primary Quantitative Analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
    Trial
  2. Trial
  3. From night-to-night and from person-to-person: dynamic phenomena of insomnia.Sleep advances : a journal of the Sleep Research Society · 2026
    Article
  4. Article
  5. Review
  6. Caregiver Experiences With an Internet-Delivered Insomnia Intervention: SHUTi-CARE Trial Primary Qualitative Analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kelly M ShafferCenter for Behavioral Health and Technology, University of Virginia, Charlottesville, VA.
Donald HedekerDepartment of Public Health Sciences, University of Chicago, Chicago, IL.
Charles M MorinDepartment of Psychology, Laval University, Québec, QC, Canada.
Karen IngersollCenter for Behavioral Health and Technology, University of Virginia, Charlottesville, VA.
Frances ThorndikePear Therapeutics, Inc, Boston, MA.
Lee M RitterbandCenter for Behavioral Health and Technology, University of Virginia, Charlottesville, VA.

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
An Internet Intervention for Insomnia: Efficacy and DisseminationR01MH086758 · NIMH · UNIVERSITY OF VIRGINIA · PI RITTERBAND, LEE M · 2010 to 2014
$2.3M
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NIMH NIH HHS R01 MH086758
6 · The paper itself

Abstract

STUDY

objectivesSleep schedule consistency is fundamental to cognitive-behavioral therapy for insomnia (CBT-I), although there is limited evidence suggesting whether it predicts treatment response. This analysis tested whether: (1) an Internet-based CBT-I program affects intraindividual variability (IIV) in sleep schedule and (2) sleep schedule IIV predicts insomnia symptom remission.

methodsThis secondary analysis compares participants (N = 303) randomized to an Internet-based CBT-I program (SHUTi-Sleep Healthy Using the Internet) or Internet-based patient education (PE). Participants reported daily bedtimes and rising times on 10 online sleep diaries collected over 2 weeks at baseline and 9-week post-intervention assessment. Participants completed the Insomnia Severity Index (ISI) at post-assessment and 6-month follow-up; symptom remission was defined by ISI < 8. Mixed effects location scale modeling was used to examine the effect of SHUTi on bedtime and rising time IIV; a novel two-staged analysis examined the effect of bedtime and rising time IIV on insomnia symptom remission.

resultsAt post-assessment, SHUTi participants reported about 30% less bedtime and 32% less rising time variability compared to PE (ps < 0.03). Bedtime and rising time IIV was not independently associated with likelihood of insomnia symptom remission at the subsequent time point (ps > 0.18), nor did sleep schedule IIV moderate treatment response (ps > 0.12).

conclusionsFindings demonstrate that an Internet-delivered CBT-I program can effectively increase users' sleep schedule consistency relative to an educational control. This consistency, however, was not related to treatment outcome when defined by insomnia symptom remission, suggesting that enforcing rigid sleep schedules for patients may not be necessary for treatment success. CLINICAL

trial registrationNCT00328250.

Indexed as

Cognitive Behavioral TherapyInternetSleep Initiation and Maintenance DisordersHumansSleepTreatment Outcomecognitive therapyinternetintraindividual variabilitypersonalized medicinerisk factorssleep initiation and maintenance disorderstreatment outcome

Identifiers

PMID32511726
PMCPMC7734473

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.