ArticlemedRxiv : the preprint server for health sciences2020
Smoking is Associated with COVID-19 Progression: A Meta-Analysis.
Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
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Abstract
objectiveTo determine the association between smoking and progression of COVID-19.
designA meta-analysis of 12 published papers. DATA SOURCE: PubMed database was searched on April 6, 2020. ELIGIBILITY CRITERIA AND DATA ANALYSIS: We included studies reporting smoking behavior of COVID-19 patients and progression of disease. Search terms included smoking, smoker*, characteristics, risk factors, outcomes, and COVID-19, COVID, coronavirus, sar cov-2, sar cov 2. There were no language limitations. One author extracted information for each study, screened the abstract or the full text, with questions resolved through discussion among both authors. A random effects meta-analysis was applied.
main outcome measuresThe study outcome was progression of COVID-19 among people who already had the disease.
resultsWe identified 12 papers with a total of 9,025 COVID-19 patients, 878 (9.7%) with severe disease and 495 with a history of smoking (5.5%). The meta-analysis showed a significant association between smoking and progression of COVID-19 (OR 2.25, 95% CI 1.49-3.39, p=0.001). Limitations in the 12 papers suggest that the actual risk of smoking may be higher.
conclusionsSmoking is a risk factor for progression of COVID-19, with smokers having higher odds of COVID-19 progression than never smokers. Physicians and public health professionals should collect data on smoking as part of clinical management and add smoking cessation to the list of practices to blunt the COVID-19 pandemic.
Identifiers
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Registered trials
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