Evidence map›Paper›PMID 32511587›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City Region.

Matthew T Maurano, Sitharam Ramaswami, Paul Zappile, Dacia Dimartino, Ludovic Boytard, André M Ribeiro-Dos-Santos, Nicholas A Vulpescu, Gael Westby, Guomiao Shen, Xiaojun Feng and 35 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors.

Matthew T MauranoInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Sitharam RamaswamiGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Paul ZappileGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Dacia DimartinoGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Ludovic BoytardCenter for Biospecimen Research and Development, NYU Langone Health, New York, USA.
André M Ribeiro-Dos-SantosInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Nicholas A VulpescuInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Gael WestbyGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Guomiao ShenDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Xiaojun FengDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Megan S HoganInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Manon Ragonnet-CroninMRC Centre for Global Infectious Disease Analysis and Department of Infectious Disease Epidemiology, Imperial College London.
Lily GeidelbergMRC Centre for Global Infectious Disease Analysis and Department of Infectious Disease Epidemiology, Imperial College London.
Christian MarierGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Peter MeynGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Yutong ZhangGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
John CadleyInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Raquel OrdoñezInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Raven LutherInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Emily HuangInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, USA.
Emily GuzmanGenome Technology Center, Division of Advanced Research Technologies, Office of Science and Research, NYU Langone Health, New York, USA.
Carolina Arguelles-GrandeCenter for Biospecimen Research and Development, NYU Langone Health, New York, USA.
Kimon V ArgyropoulosDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Margaret BlackDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Antonio SerranoDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Melissa E CallDepartment of Dermatology, NYU Grossman School of Medicine, New York, USA.
Min Jae KimDepartment of Dermatology, NYU Grossman School of Medicine, New York, USA.
Brendan BelovaracDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Tatyana GindinDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Andrew LytleDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Jared PinnellDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Theodore VougiouklakisDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
John ChenMedical Center IT, NYU Langone Health, New York, USA.
Lawrence H LinDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Amy RapkiewiczDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Vanessa RaabeDivision of Infectious Diseases and Immunology, Department of Medicine and NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, USA.
Marie I SamanovicDepartment of Medicine, NYU Grossman School of Medicine, New York, USA.
George JourDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Iman OsmanCenter for Biospecimen Research and Development, NYU Langone Health, New York, USA.
Maria Aguero-RosenfeldDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Mark J MulliganDivision of Infectious Diseases and Immunology, Department of Medicine and NYU Langone Vaccine Center, NYU Grossman School of Medicine, New York, USA.
Erik M VolzMRC Centre for Global Infectious Disease Analysis and Department of Infectious Disease Epidemiology, Imperial College London.
Paolo CotziaDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Matija SnuderlDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Adriana HeguyDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU) - DMID 21-0012UM1AI148574 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Angelica Cifuentes Kottkamp, Anoma Nellore · 2020 to 2026
$23.9M
Genomic organization of long-distance gene regulationR35GM119703 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MAURANO, MATTHEW THOMAS · 2016 to 2020
$2.1M
NCI NIH HHS P30 CA016087NIAID NIH HHS UM1 AI148574NIGMS NIH HHS R35 GM119703
6 · The paper itself

Abstract

Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report the analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area during the COVID-19 outbreak in Spring 2020. The majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe. Our data are consistent with numerous seeds from multiple sources and a prolonged period of unrecognized community spreading. This work highlights the complementary role of genomic surveillance in addition to traditional epidemiological indicators.

Identifiers

PMID32511587
PMCPMC7276014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.