Evidence map›Paper›PMID 32511356›Full record

ArticlebioRxiv : the preprint server for biology2020

Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates.

Joana Damas, Graham M Hughes, Kathleen C Keough, Corrie A Painter, Nicole S Persky, Marco Corbo, Michael Hiller, Klaus-Peter Koepfli, Andreas R Pfenning, Huabin Zhao and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 108 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 5 countries.

Joana DamasThe Genome Center, University of California Davis, Davis, CA 95616, USA.
Graham M HughesSchool of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland.
Kathleen C KeoughUniversity of California San Francisco, San Francisco, CA 94117, USA.
Corrie A PainterBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nicole S PerskyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Marco CorboThe Genome Center, University of California Davis, Davis, CA 95616, USA.
Michael HillerMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Klaus-Peter KoepfliSmithsonian Conservation Biology Institute, Center for Species Survival, National Zoological Park, Front Royal, VA 22630, Washington, DC 20008 USA.
Andreas R PfenningDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Huabin ZhaoDepartment of Ecology and Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Diane P GenereuxBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ross SwoffordBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Katherine S PollardUniversity of California San Francisco, San Francisco, CA 94117, USA.
Oliver A RyderSan Diego Zoo Institute for Conservation Research, Escondido, CA 92027, USA.
Martin T NweeiaHarvard School of Dental Medicine, Boston, MA 02115, USA.
Kerstin Lindblad-TohBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Emma C TeelingSchool of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland.
Elinor K KarlssonBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Harris A LewinThe Genome Center, University of California Davis, Davis, CA 95616, USA.
Broad Institute · USGladstone Institutes · USUniversity College Dublin · IEUniversity of California, Davis · USCarnegie Mellon University · USJohn Muir Health · USMax Planck Institute for the Physics of Complex Systems · DESmithsonian Conservation Biology Institute · USSmithsonian Institution · USUniversity of California San Diego · USWuhan University · CN

Funding

The 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome.R01HG008742 · NHGRI · BROAD INSTITUTE, INC. · PI BIRREN, BRUCE W., KARLSSON, ELINOR · 2016 to 2020
$2.8M
NHGRI NIH HHS R01 HG008742
6 · The paper itself

Abstract

The novel coronavirus SARS-CoV-2 is the cause of Coronavirus Disease-2019 (COVID-19). The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of 410 vertebrates, including 252 mammals, to study cross-species conservation of ACE2 and its likelihood to function as a SARS-CoV-2 receptor. We designed a five-category ranking score based on the conservation properties of 25 amino acids important for the binding between receptor and virus, classifying all species from

Indexed as

ACE2comparative genomicsCOVID-19evolutionhost rangeSARS-CoV-2species conservation

Identifiers

PMID32511356
PMCPMC7263403
OpenAlexW3016786828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.