ArticlebioRxiv : the preprint server for biology2020
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
Open access · greenAbstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 453 citations in OpenAlex.
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- Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing.PLoS pathogens · 2021Review
- RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.PLoS genetics · 2021Article
- The Immunopathogenesis of Neuroinvasive Lesions of SARS-CoV-2 Infection in COVID-19 Patients.Frontiers in neurology · 2021Review
- In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species.PLoS computational biology · 2020Article
- Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.PLoS pathogens · 2020Article
- Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.American journal of physiology. Cell physiology · 2020Article
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Authors and funding
100 authors at 13 institutions in 4 countries.
David E GordonQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Gwendolyn M JangQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-7806-9874
Mehdi BouhaddouQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-9526-1427
Jiewei XuQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8647-4172
Kirsten ObernierQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-4025-1299
Matthew J O'MearaDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-3128-5331
Jeffrey Z GuoQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Danielle L SwaneyQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-6119-6084
Tia A TumminoQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-9155-820X
Ruth HuettenhainQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-0896-5910
Robyn M KaakeQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8341-3067
Alicia L RichardsQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-4869-2945
Beril TutuncuogluQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-5458-2988
Helene FoussardQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Jyoti BatraQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-2335-0607
Kelsey HaasQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-1463-6726
Maya ModakQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-0670-6683
Minkyu KimQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-9317-1658
Paige HaasQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-8303-457X
Benjamin J PolaccoQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-1570-9234
Hannes BrabergQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-7070-2257
Jacqueline M FabiusQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Manon EckhardtQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-8143-6129
Margaret SoucherayQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-0370-6653
Melanie J BennettQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Merve CakirQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-1803-5693
Michael J McGregorQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-5281-5736
Qiongyu LiQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-3654-0378
Zun Zar Chi NaingQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-6320-5084
Yuan ZhouQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-1393-5476
Shiming PengQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Ilsa T KirbyQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-6120-7011
James E MelnykQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-1915-8089
John S ChorbaQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-6397-6348
Kevin LouQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-4939-4381
Shizhong A DaiQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-9679-2353
Wenqi ShenQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8657-4931
Ying ShiQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-9263-4320
Ziyang ZhangQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-0541-7211
Inigo Barrio-HernandezEuropean Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-5686-0451
Danish MemonEuropean Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-1365-0710
Claudia Hernandez-ArmentaEuropean Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0003-1510-1253
Christopher J P MathyQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-5546-9733
Tina PericaQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-3152-8425
Kala B PillaQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8327-1687
Sai J GanesanQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8335-2866
Daniel J SaltzbergQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-8641-6194
Rakesh RamachandranQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-7196-5078
Xi LiuQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Sara B RosenthalCenter for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego.ORCID 0000-0002-6548-9658
Lorenzo CalvielloDepartment of Cell and Tissue Biology, University of California, San Francisco.ORCID 0000-0002-5600-0988
Srivats VenkataramananDepartment of Cell and Tissue Biology, University of California, San Francisco.ORCID 0000-0002-2507-401X
Jose Liboy-LugoDepartment of Cell and Tissue Biology, University of California, San Francisco.
Yizhu LinDepartment of Cell and Tissue Biology, University of California, San Francisco.ORCID 0000-0002-6369-8077
Stephanie A WankowiczQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-4225-7459
Markus BohnDepartment of Pharmaceutical Chemistry, University of California, San Francisco.ORCID 0000-0002-0369-1922
Phillip P SharpUniversity of California San Francisco, Department of Cellular and Molecular Pharmacology, San Francisco, CA, 94158, USA.
Raphael TrenkerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0003-1748-0517
Janet M YoungDivision of Basic Sciences, Fred Hutchinson Cancer Research Center.ORCID 0000-0001-8220-8427
Devin A CaveroJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-3830-6625
Joseph HiattMedical Scientist Training Program, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-5326-2616
Theodore L RothMedical Scientist Training Program, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-3970-9573
Ujjwal RathoreJ. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-0329-7431
Advait SubramanianQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-0557-9771
Julia NoackQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Mathieu HubertVirus and Immunity Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Ferdinand RoeschViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.
Thomas ValletViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.
Björn MeyerViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.
Kris M WhiteDepartment for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-0889-0506
Lisa MiorinDepartment for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-0989-3178
Oren S RosenbergDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Kliment A VerbaQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
David AgardQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-3512-695X
Melanie OttJ. David Gladstone Institutes, San Francisco, CA 94158, USA.
Michael EmermanDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103.ORCID 0000-0002-4181-6335
Davide RuggeroDepartment of Urology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9444-5865
Adolfo García-SastreDepartment for Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-6551-1827
Natalia JuraQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-5129-641X
Mark von ZastrowQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-1375-6926
Jack TauntonQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-9627-5898
Alan AshworthQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.
Olivier SchwartzVirus and Immunity Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.ORCID 0000-0002-0729-1475
Marco VignuzziViral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.ORCID 0000-0002-4400-771X
Christophe d'EnfertDirection Scientifique, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.ORCID 0000-0002-6235-3886
Shaeri MukherjeeQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-3820-0174
Matt JacobsonDepartment of Pharmaceutical Chemistry, University of California, San Francisco.
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center.ORCID 0000-0001-6005-0016
Danica G FujimoriQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-4066-9417
Trey IdekerDivision of Genetics, Department of Medicine, University of California San Diego.ORCID 0000-0002-1708-8454
Charles S CraikDepartment of Pharmaceutical Chemistry, University of California, San Francisco.ORCID 0000-0001-7704-9185
Stephen FloorDepartment of Cell and Tissue Biology, University of California, San Francisco.ORCID 0000-0002-9965-9694
James S FraserQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-5080-2859
John GrossQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-1377-4705
Andrej SaliQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-0435-6197
Tanja KortemmeQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-8494-680X
Pedro BeltraoEuropean Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.ORCID 0000-0002-2724-7703
Kevan ShokatQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0001-8590-7741
Brian K ShoichetQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0002-6098-7367
Nevan J KroganQBI COVID-19 Research Group (QCRG), San Francisco, CA, 94158, USA.ORCID 0000-0003-4902-337X
Gladstone Institutes · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USCentre National de la Recherche Scientifique · FREuropean Bioinformatics Institute · GBIcahn School of Medicine at Mount Sinai · USInstitut Pasteur · FRSan Francisco Foundation · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAUniversity of California San Diego · USFred Hutch Cancer Center · USQuality Biological · USUniversity of Michigan · US
Funding
The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5MVirology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2MSARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2MRESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2018 to 2026
$21.4MX-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MDevelopment and Testing of New Computational Methods for Ligand Discovery and MechanismR35GM122481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian K Shoichet · 2017 to 2026
$8.5MRESEARCH TRAINING IN CHEMISTRY AND CHEMICAL BIOLOGYT32GM064337 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2002 to 2021
$7.8MBMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6MNovel VP30-host Interactions that Negatively Regulate Ebola Virus InfectionR01AI143292 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K., BASLER, CHRISTOPHER F · 2019 to 2023
$4.0MCytoscape: A Modeling Platform for Biomolecular NetworksR01HG009979 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2017 to 2021
$3.5MDiscovery of novel, ubiquitin-regulated mechanisms of TB control by macrophagesR01AI120694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, JEFFERY S, KROGAN, NEVAN J · 2015 to 2019
$3.3MNCI NIH HHS F32 CA236347NCI NIH HHS R01 CA221969NCI NIH HHS R01 CA244550NHGRI NIH HHS R01 HG009979NHLBI NIH HHS K08 HL124068NIAID NIH HHS P01 AI063302NIAID NIH HHS P01 AI120943NIAID NIH HHS P50 AI150476NIAID NIH HHS R01 AI120694NIAID NIH HHS R01 AI122747NIAID NIH HHS R01 AI143292NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI135990NIGMS NIH HHS R35 GM122481NIGMS NIH HHS T32 GM008284NIGMS NIH HHS T32 GM064337NIGMS NIH HHS T32 GM067547
Abstract
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, and caused worldwide social and economic disruption
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.