Evidence map›Paper›PMID 32511326›Full record

ArticlebioRxiv : the preprint server for biology2020

Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium.

Satria P Sajuthi, Peter DeFord, Nathan D Jackson, Michael T Montgomery, Jamie L Everman, Cydney L Rios, Elmar Pruesse, James D Nolin, Elizabeth G Plender, Michael E Wechsler and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 69 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 2 countries.

Satria P SajuthiCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Peter DeFordCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Nathan D JacksonCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Michael T MontgomeryCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Jamie L EvermanCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Cydney L RiosCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Elmar PruesseCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
James D NolinCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Elizabeth G PlenderCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
Michael E WechslerDepartment of Medicine, National Jewish Health, Denver, CO, 80206 USA.
Angel Cy MakDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Celeste EngDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Sandra SalazarDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Vivian MedinaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Eric M WohlfordDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Scott HuntsmanDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Soren GermerNew York Genome Center, NYC, New York.
Michael C ZodyNew York Genome Center, NYC, New York.
Gonçalo AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Hyun Min KangCenter for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Rajesh KumarAnn and Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, III.
Sam OhDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Jose Rodriguez-SantanaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Esteban G BurchardDepartment of Medicine, Therapeutic Sciences University of California San Francisco, San Francisco, CA.
Max A SeiboldCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, 80206 USA.
National Jewish Health · USUniversity of California, San Francisco · USCentro de Neumologia Pediatrica · PRNew York Genome Center · USUniversity of Michigan · USUniversity of Washington · USLurie Children's Hospital · US

Funding

New York Center for Collaborative Research In Common Disease Genomics: Genome Aggregation and Joint Variant Calling for CCDG Freeze2UM1HG008901 · NHGRI · NEW YORK GENOME CENTER · PI MANIATIS, THOMAS P, WIGLER, MICHAEL H · 2016 to 2020
$56.6M
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Natural History of Viral Induced Airway Dysfunction and Asthma in Minority ChildrenU01HL138626 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RODRIGUEZ-SANTANA, JOSE, SEIBOLD, MAX A · 2018 to 2022
$10.0M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Transcriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Optimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2M
NHGRI NIH HHS U01 HG009080NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG008901NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL140218NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL141992NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL138626NIEHS NIH HHS HHSN268201600032CNIEHS NIH HHS R01 ES015794NIGMS NIH HHS T32 GM007546NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and the spike protein activator, TMPRSS2. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway, through the analysis of nasal airway transcriptome data from 695 children. We identify expression quantitative trait loci (eQTL) for both

Identifiers

PMID32511326
PMCPMC7239056
OpenAlexW3016112702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.