Evidence map›Paper›PMID 32511305›Full record

ArticlebioRxiv : the preprint server for biology2020

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19.

Jing Xing, Rama Shankar, Aleksandra Drelich, Shreya Paithankar, Evgenii Chekalin, Thomas Dexheimer, Mei-Sze Chua, Surender Rajasekaran, Chien-Te Kent Tseng, Bin Chen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 38 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jing XingDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Rama ShankarDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Aleksandra DrelichDepartments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Shreya PaithankarDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Evgenii ChekalinDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Thomas DexheimerDepartment of Pharmacology and Toxicology, Michigan State University, Grand Rapids, Michigan, USA.
Mei-Sze ChuaDepartment of Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Surender RajasekaranDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Chien-Te Kent TsengDepartments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Bin ChenDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, Michigan, USA.
Michigan State University · USThe University of Texas Medical Branch at Galveston · USHelen DeVos Children's Hospital · USStanford University · US

Funding

Repurpose open data to discover therapeutics for understudied diseasesR01GM134307 · NIGMS · MICHIGAN STATE UNIVERSITY · PI CHEN, BIN · 2019 to 2023
$2.5M
Integrating transcriptomic, proteomic and pharmacogenomic data to inform individualized therapy in cancersK01ES028047 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, BIN · 2017 to 2020
$682k
NIEHS NIH HHS K01 ES028047NIGMS NIH HHS R01 GM134307
6 · The paper itself

Abstract

The repurposing of existing drugs offers the potential to expedite therapeutic discovery against the current COVID-19 pandemic caused by the SARS-CoV-2 virus. We have developed an integrative approach to predict repurposed drug candidates that can reverse SARS-CoV-2-induced gene expression in host cells, and evaluate their efficacy against SARS-CoV-2 infection

Indexed as

CoronavirusCOVID-19drug repurposinggene expression reversal

Identifiers

PMID32511305
PMCPMC7217282
OpenAlexW3015956745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.