Evidence map›Paper›PMID 32511231›Full record

ArticlePLoS computational biology2020

Measurable health effects associated with the daylight saving time shift.

Hanxin Zhang, Torsten Dahlén, Atif Khan, Gustaf Edgren, Andrey Rzhetsky

Abstract read
In one paragraph

Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Health-Framed Messaging and Its Impact on Attitudes Toward Daylight Saving Time.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Permanent standard time is the optimal choice for health and safety: an American Academy of Sleep Medicine position statement.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Circadian Mechanisms in Medicine.The New England journal of medicine · 2021
    Review
  19. Daylight Saving Time and Spontaneous Deliveries: A Case-Control Study in Italy.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanxin ZhangCommittee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0001-5069-634X
Torsten DahlénDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Atif KhanDepartment of Medicine, and Institute of Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0002-6006-2620
Gustaf EdgrenDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Andrey RzhetskyCommittee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0001-6959-7405

Funding

Modeling the temporal succession of phenotypes & environnnental cuesP50MH094267 · NIMH · UNIVERSITY OF CHICAGO · PI RZHETSKY, ANDREY · 2011 to 2015
$10.2M
MAPGen Knowledge Base (MAPGenKB) and Coordination CenterU01HL108634 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, XIANGHONG JASMINE · 2011 to 2015
$5.3M
Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma GenesR01HL122712 · NHLBI · UNIVERSITY OF CHICAGO · PI OBER, CAROLE, RZHETSKY, ANDREY · 2015 to 2018
$3.1M
NHLBI NIH HHS R01 HL122712NHLBI NIH HHS U01 HL108634NIMH NIH HHS P50 MH094267
6 · The paper itself

Abstract

The transition to daylight saving time (DST) is beneficial for energy conservation but at the same time it has been reported to increase the risk of cerebrovascular and cardiovascular problems. Here, we evaluate the effect of the DST shift on a whole spectrum of diseases-an analysis we hope will be helpful in weighing the risks and benefits of DST shifts. Our study relied on a population-based, cross-sectional analysis of the IBM Watson Health MarketScan insurance claim dataset, which incorporates over 150 million unique patients in the US, and the Swedish national inpatient register, which incorporates more than nine million unique Swedes. For hundreds of sex- and age-specific diseases, we assessed effects of the DST shifts forward and backward by one hour in spring and autumn by comparing the observed and expected diagnosis rates after DST shift exposure. We found four prominent, elevated risk clusters, including cardiovascular diseases (such as heart attacks), injuries, mental and behavioral disorders, and immune-related diseases such as noninfective enteritis and colitis to be significantly associated with DST shifts in the United States and Sweden. While the majority of disease risk elevations are modest (a few percent), a considerable number of diseases exhibit an approximately ten percent relative risk increase. We estimate that each spring DST shift is associated with negative health effects-with 150,000 incidences in the US, and 880,000 globally. We also identify for the first time a collection of diseases with relative risks that appear to decrease immediately after the spring DST shift, enriched with infections and immune system-related maladies. These diseases' decreasing relative risks might be driven by the documented boosting effect of a short-term stress (such as that experienced around the spring DST shift) on the immune system.

Indexed as

SeasonsTimeCircadian RhythmCross-Sectional StudiesFemaleHumansMaleMyocardial InfarctionRisk FactorsSwedenUnited States

Identifiers

PMID32511231
PMCPMC7302868

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.