Evidence map›Paper›PMID 32511092›Full record

ArticleeLife2020

Predicting geographic location from genetic variation with deep neural networks.

C J Battey, Peter L Ralph, Andrew D Kern

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Estimating human mobility in Holocene Western Eurasia with large-scale ancient genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Pooled it
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  9. Coalescence and translation: A language model for population genetics.Proceedings of the National Academy of Sciences of the United States of America · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

C J BatteyUniversity of Oregon, Institute of Ecology and Evolution, Eugene, United States.ORCID 0000-0002-9958-4282
Peter L RalphUniversity of Oregon, Institute of Ecology and Evolution, Eugene, United States.
Andrew D KernUniversity of Oregon, Institute of Ecology and Evolution, Eugene, United States.ORCID 0000-0003-4381-4680

Funding

Deep learning for population geneticsR01HG010774 · NHGRI · UNIVERSITY OF OREGON · PI ANDREW D KERN · 2020 to 2026
$3.2M
POPULATION GENOMICS OF ADAPTATIONR01GM117241 · NIGMS · UNIVERSITY OF OREGON · PI KERN, ANDREW D · 2017 to 2020
$1.2M
NHGRI NIH HHS R01 HG010774NIGMS NIH HHS R01 GM117241
6 · The paper itself

Abstract

Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. This allows us to predict the location of origin of a genetic sample by comparing it to a set of samples of known geographic origin. Here, we describe a deep learning method, which we call Locator, to accomplish this task faster and more accurately than existing approaches. In simulations, Locator infers sample location to within 4.1 generations of dispersal and runs at least an order of magnitude faster than a recent model-based approach. We leverage Locator's computational efficiency to predict locations separately in windows across the genome, which allows us to both quantify uncertainty and describe the mosaic ancestry and patterns of geographic mixing that characterize many populations. Applied to whole-genome sequence data from

Indexed as

Genetic VariationNeural Networks, ComputerAnimal DistributionAnimalsAnophelesDemographyGenome, HumanGenomicsGenotypeHumansPlasmodium falciparumAnophelesevolutionary biologygeneticsgenomicshumanPlasmodium

Identifiers

PMID32511092
PMCPMC7324158

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.