ArticleHuman brain mapping2020
Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Can EEG-Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial.Brain and behavior · 2025Trial
- Closed-Loop Infraslow Brain-Computer Interface can Modulate Cortical Activity and Connectivity in Individuals With Chronic Painful Knee Osteoarthritis: A Secondary Analysis of a Randomized Placebo-Controlled Clinical Trial.Clinical EEG and neuroscience · 2025Trial
- Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- [Biomarkers in complex regional pain syndrome].Schmerz (Berlin, Germany) · 2025Review
- An Integrative Review of Potential Diagnostic Biomarkers for Complex Regional Pain Syndrome.Journal of clinical medicine · 2025Review
- Aberrant regional homogeneity in multiple frequency bands in patients with alcohol use disorder.Frontiers in psychiatry · 2025Article
- Sex-Specific White Matter Abnormalities Across the Dynamic Pain Connectome in Neuropathic Pain: A Fixel-Based Analysis Study.Human brain mapping · 2025Article
- Sensory processing in medically unexplained pain syndrome. A systematic review.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review.BMJ neurology open · 2025Article
- Association Between Chronic Pain and Jumping-to-Conclusions Behaviour.Pain research & management · 2025Article
- Trauma-Based Sexually Dimorphic Changes in the Connectome and Its Association with Central Sensitization Syndromes-A Systematic Review.Brain sciences · 2024Review
- The Treatment of Chronic Complex Regional Pain Syndrome with Novel Neuromodulatory Sound Waves: A Case Report.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- The complex regional pain syndrome: Diagnosis and management strategies.Neurosciences (Riyadh, Saudi Arabia) · 2023Review
- Imaging Modalities and Their Findings in Patients With Complex Regional Pain Syndrome: A Review.Cureus · 2023Review
- Aberrant Resting-state Functional Connectivity in Complex Regional Pain Syndrome: A Network-based Statistics Analysis.Experimental neurobiology · 2023Article
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- Altered basal ganglia infraslow oscillation and resting functional connectivity in complex regional pain syndrome.Journal of neuroscience research · 2022Article
- Exploring alterations in sensory pathways in migraine.The journal of headache and pain · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder that typically occurs in the limbs, usually the upper limb. CRPS usually develops from a peripheral event but its maintenance relies on changes within the central nervous system. While functional abnormalities in the thalamus and primary somatosensory cortex (S1) of the brain are some of the most consistently reported brain findings in CRPS, the mechanisms are yet to be explored in full, not least of all how these two regions interact and how they might relate to clinical deficits, such as the commonly reported poor tactile acuity in this condition. This study recruited 15 upper-limb CRPS subjects and 30 healthy controls and used functional magnetic resonance imaging (fMRI) to investigate infra-slow oscillations (ISOs) in critical pain regions of the brain in CRPS. As hypothesised, we found CRPS was associated with increases in resting signal intensity ISOs (0.03-0.06 Hz) in the thalamus contralateral to the painful limb in CRPS subjects. Interestingly, there was no such difference between groups in S1, however CRPS subjects displayed stronger thalamo-S1 functional connectivity than controls, and this was related to pain. As predicted, CRPS subjects displayed poor tactile acuity on the painful limb which, interestingly, was also related to thalamo-S1 functional connectivity strength. Our findings provide novel evidence of altered patterns of resting activity and connectivity in CRPS which may underlie altered thalamocortical loop dynamics and the constant perception of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.