Evidence map›Paper›PMID 32510663›Full record

ArticleJournal of cellular physiology2021

Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca

Markus V Olsen, Anne V Lyngstadaas, Jeffrey A Bair, Robin R Hodges, Tor P Utheim, Charles N Serhan, Darlene A Dartt

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Resolvin D2 uses multiple CaJournal of cellular physiology · 2022
    Article
  10. Review
  11. Article
  12. Resolution of Inflammation in Retinal Disorders: Briefly the State.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Markus V OlsenSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.
Anne V LyngstadaasSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.
Jeffrey A BairSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.
Robin R HodgesSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.ORCID 0000-0001-5867-9130
Tor P UtheimSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.
Charles N SerhanDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Darlene A DarttSchepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts.
Massachusetts Eye and Ear Infirmary · USOslo University Hospital · NOBrigham and Women's Hospital · US

Funding

Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its ResolutionR01EY019470 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 2009 to 2023
$7.4M
BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
NEI NIH HHS R01 EY019470NIGMS NIH HHS R01 GM038765
6 · The paper itself

Abstract

Mucin secretion from conjunctival goblet cells forms the tear film mucin layer and requires regulation to function properly. Maresin 1 (MaR1) is a specialized proresolving mediator produced during the resolution of inflammation. We determined if MaR1 stimulates mucin secretion and signaling pathways used. Cultured rat conjunctival goblet cells were used to measure the increase in intracellular Ca

Indexed as

AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedConjunctivaDocosahexaenoic AcidsGoblet CellsMaleMucinsProtein Kinase CRatsRats, Sprague-DawleySignal TransductionTearsType C Phospholipases7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Docosahexaenoic AcidsMucinsProtein Kinase CType C Phospholipasesconjunctivagoblet cellsignal transductionspecialized proresolving mediator (SPM)

Identifiers

PMID32510663
PMCPMC7722204
OpenAlexW3033347668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.